7410-54-0

Basic information

• Product Name: (1E)-1-(4-methylphenyl)ethanone thiosemicarbazone
• Synonyms: (2E)-2-[1-(4-Methylphenyl)ethylidene]hydrazinecarbothioamide
• CAS NO: 7410-54-0
• Molecular Formula: C₁₀H₁₃N₃S
• Molecular Weight: 207.2953
• Mol File: 7410-54-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 335.201°C at 760 mmHg
• Flash Point: 156.524°C
• Density: 1.163g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: (1E)-1-(4-methylphenyl)ethanone thiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: (1E)-1-(4-methylphenyl)ethanone thiosemicarbazone(7410-54-0)
• EPA Substance Registry System: (1E)-1-(4-methylphenyl)ethanone thiosemicarbazone(7410-54-0)

Safety Data

• Hazardous Substances Data: 7410-54-0(Hazardous Substances Data)

Usage

General Description

(1E)-1-(4-methylphenyl)ethanone thiosemicarbazone, also known as p-methylacetophenone thiosemicarbazone, is a chemical compound that belongs to the class of thiosemicarbazones. It is derived from the condensation of p-methylacetophenone with thiosemicarbazide. Thiosemicarbazones are known for their diverse biological activities, including antiviral, antitumor, and antiprotozoal properties. (1E)-1-(4-methylphenyl)ethanone thiosemicarbazone has shown potential as a metal chelator, with potential applications in medicine and industry. Its ability to chelate metal ions has also been explored for its potential in treating metal ion overloads and related disorders in the body. Overall, this compound has garnered interest as a versatile chemical with potential applications in various fields.

Upstream product

• 56587-84-9 (1E,2E)-1,2-bis(1-(p-tolyl)ethylidene)hydrazine 
• 79-19-6 thiosemicarbazide 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 37050-14-9 1-p-tolyl-ethanone (4-thiophen-2-yl-thiazol-2-yl)-hydrazone 
• 1029475-64-6 (1-amino-2-thioxo-4-(p-tolyl)-1,2-dihydropyrimidin-5-yl)(p-tolyl)methanone 

Relevant articles and documents

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Microwave-assisted Vilsmeier-Haack synthesis of Pyrazole-4-carbaldehydes

The synthesis of 4-formylpyrazoles using Vilsmeier-Haack reagent is a common protocol in pyrazole chemistry. An efficient microwave-assisted synthesis of 4-formylpyrazoles by employing Vilsmeier-Haack reagent (OPC-VH) derived from phthaloyl dichloride/dimethylformamide has been described. This method offers the advantages of operational simplicity, avoiding the use of POCl3 as toxic reagents and reuse of the by-product in the preparation of phthaloyl dichloride.

Microwave-assisted synthesis and biological evaluation of pyrazole-4-carbonitriles as antimicrobial agents

An efficient microwave-assisted method of synthesis of pyrazole-4-carbonitriles has been developed. Condensation of pyrazole-4-carbaldehydes with hydroxylamine hydrochloride followed by reaction of the resulting oximes with the Vilsmeier-Haack reagent pre-formed from phthaloyl dichloride and dimethylformamide under microwave irradiation afforded the corresponding pyrazole-4-carbonitriles in 73percent to 91percent yield. The operational simplicity, avoidance of toxic reagents such as POCl3, shorter reaction time, higher yield compared to the classical version, easy work up, and the use of the by-product in the regeneration of phthaloyl dichloride are the advantages of this methodology. All the target compounds were tested for antimicrobial activity against Gram-positive bacteria Bacillus cereus and Staphylococcus aureus; Gram-negative bacteria Escherichia coli and Yersinia enterocolitica, and the fungal species Candida albicans.