74115-15-4

Basic information

• Product Name: 3,6-BIS(2-CHLOROPHENYL)-1,2-DIHYDRO-1,2,4,5-TETRAZINE
• Synonyms: 3,6-BIS(2-CHLOROPHENYL)-1,2-DIHYDRO-1,2,4,5-TETRAZINE
• CAS NO: 74115-15-4
• Molecular Formula: C₁₄H₁₀Cl₂N₄
• Molecular Weight: 305.16
• Mol File: 74115-15-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 209-210 °C(Solv: ethanol (64-17-5))
• Boiling Point: 426.6±55.0 °C(Predicted)
• Appearance: /
• Density: 1.45±0.1 g/cm3(Predicted)
• PKA: 2.65±0.20(Predicted)
• CAS DataBase Reference: 3,6-BIS(2-CHLOROPHENYL)-1,2-DIHYDRO-1,2,4,5-TETRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-BIS(2-CHLOROPHENYL)-1,2-DIHYDRO-1,2,4,5-TETRAZINE(74115-15-4)
• EPA Substance Registry System: 3,6-BIS(2-CHLOROPHENYL)-1,2-DIHYDRO-1,2,4,5-TETRAZINE(74115-15-4)

Safety Data

• Hazardous Substances Data: 74115-15-4(Hazardous Substances Data)

Upstream product

• 792-39-2 bis(α,2-dichlorobenzylidene)hydrazine 
• 873-32-5 2-Chlorobenzonitrile 

Downstream Products

• 74115-24-5 bisclofentezin 
• 80590-11-0 3,5-bis(2-chlorophenyl)-4-amino-1H-1,2,4-triazole 

Relevant articles and documents

Hydrogen-bonding patterns in two structural isomers of 3,6-bis(2-chlorophenyl)-1,4-dihydro-1,2,4,5-tetrazine

The hydrogen bonding patterns in the structural isomers of 3,6-bis(2-chlorophenyl)-1,4-dihydro-1,2,4,5-tetrazine were discussed. The molecular structure of the isomers consisted of a six-membered central tetrazine ring and two chlorophenyl rings. A contribution from weak interaction to the strong hydrogen-bond was observed. It was found that the main chains of the isomers formed close-packed structure as the zigzag chains were connected together using hydrogen bonds.

Synthesis and antitumor activity of s-tetrazine derivatives

Fifty-five compounds of s-tetrazine derivative including hexahydro-, 1,6-dihydro, 1,4-dihydro-, 1,2-dihydro- and aromatic s-tetrazine were prepared. Their antitumor activities were evaluated in vitro by MTT method for P-388 cell and SRB method for A-549 cell. The results show that there are 9 compounds which in 10-6 μM have more than 50% inhibition rate to A-549 cancer cell growth, and 7 compounds in 10-6 μM have more than 50% inhibition rate to P-388 cancer cell growth. The IC50 of compound 3q for P-388, Bel-7402, MCF-7 and A-549 are 0.6 μM, 0.6 μM, 0.5 μM and 0. 7 μM, respectively. So s-tetrazine derivative is a kind of compound which possesses potential antitumor activities and is worth to research further.