74123-82-3Relevant academic research and scientific papers
PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS
-
, (2021/10/11)
The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.
A Convenient Synthesis of Monocyclic β-Lactams by Means of Solid-Liquid Phase Transfer Reactions
Takahata, Hiroki,Ohnishi, Yoshinori,Takehara, Hiroyuki,Tsuritani, Kazuko,Yamazaki, Takao
, p. 1063 - 1068 (2007/10/02)
The intramolecular N-alkylation of β-bromopropionamides (1) under phase transfer conditions afforded monocyclic N-substituted β-lactams (2) in high yields.In a similar manner, cyclization by N1-C4 bond formation gave 4-benzoyl-2-azet
A CONVENIENT SYNTHESIS OF MONOCYCLIC β-LACTAMS
Takahata, Hiroki,Ohnishi, Yoshinori,Yamazaki, Takao
, p. 467 - 469 (2007/10/02)
The intramolecular N-alkylation of β-bromopropionamide (1) under phase transfer conditions gave monocyclic β-lactams (2) in high yields.
