741265-22-5

Upstream product

• 741265-14-5 2-(4-chloro-2-methyl-phenylamino)-6-trifluoromethyl-nicotinonitrile 

Downstream Products

• 1018788-65-2 C₁₉H₁₄ClF₃N₄O 
• 1018788-47-0 3-pyridyl 2-(4-chloro-2-methylphenylamino)-6-(trifluoromethyl)nicotinate 
• 1018788-41-4 C₂₁H₁₆ClF₃N₂O₃ 
• 1018788-45-8 3,5-dimethoxyphenyl 2-(4-chloro-2-methylphenylamino)-6-(trifluoromethyl)nicotinate 
• 1018788-67-4 C₂₁H₂₂ClF₃N₄O₃ 
• 1018788-73-2 (2-(4-chloro-2-methylphenylamino)-6-(trifluoromethyl)pyridin-3-yl)(4-(4-methoxyphenyl)piperazin-1-yl)methanone 
• 1018788-33-4 C₂₀H₁₃Cl₂F₃N₂O₂ 
• 1018788-31-2 C₂₀H₁₃Cl₂F₃N₂O₂ 
• 1018788-53-8 C₂₁H₁₇ClF₃N₃O₂ 
• 1018788-51-6 C₂₁H₁₄ClF₆N₃O 
• 1018788-35-6 C₂₀H₁₃Cl₂F₃N₂O₂ 
• 1018788-43-6 4-methoxyphenyl 2-(4-chloro-2-methylphenylamino)-6-(trifluoromethyl)nicotinate 
• 1018788-61-8 C₂₀H₁₄Cl₂F₃N₃O 
• 1018788-71-0 (2-(4-chloro-2-methylphenylamino)-6-(trifluoromethyl)pyridin-3-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanone 

Relevant academic research and scientific papers

Synthesis and evaluation of antitumoral activity of ester and amide derivatives of 2-arylamino-6-trifluoromethyl-3-pyridinecarboxylic acids

The synthesis and antitumoral activity of ester and amide derivatives of 2-arylamino-6-trifluoromethyl-3-pyridinecarboxylic acids 8-58 is described. Trifluoromethylpyridine derivatives 8-58 were evaluated for their anticancer activity toward human tumoral cell lines by the National Cancer Institute (NCI). Most of them possess encouraging anticancer activity, having GI50 values in the low micromolar to nanomolar concentration range. The 3,4,5-trimethoxyphenylamide 44 was the most active, and it is now under review by NCI Biological Evaluation Committee for possible further studies.

Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity

A new series of 2-arylamino-6-trifluoromethyl-3-carboxylic acid derivatives was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to aspirin, ibuprofen and flufenamic acid some of the new compo