74129-15-0Relevant academic research and scientific papers
Direct Triflylation of Benzylic C—H Bonds with Pyridine as a Directing Group
Yang, Jun,Hu, Juanjuan,Huang, Yangen,Xu, Xiuhua,Qing, Fengling
supporting information, p. 867 - 870 (2017/06/27)
The first example of benzylic C—H triflylation was accomplished with pyridine as a directing group. The reaction of various 2-benzylpyridines and (CF3SO2)2O in the presence of NEt3 in CH2Cl2 proceeded smoothly to afford the corresponding benzyl triflones in moderate to high yields.
Versatile C(sp2)?C(sp3) Ligand Couplings of Sulfoxides for the Enantioselective Synthesis of Diarylalkanes
Dean, William M.,?iau?iulis, Mindaugas,Storr, Thomas E.,Lewis, William,Stockman, Robert A.
supporting information, p. 10013 - 10016 (2016/08/16)
The reaction of chiral (hetero)aryl benzyl sulfoxides with Grignard reagents affords enantiomerically pure diarylalkanes in up to 98 % yield and greater than 99.5 % enantiomeric excess. This ligand coupling reaction is tolerant to multiple substitution patterns and provides access to diverse areas of chemical space in three operationally simple steps from commercially available reagents. This strategy provides orthogonal access to electron-deficient heteroaromatic compounds, which are traditionally synthesized by transition metal catalyzed cross-couplings, and circumvents common issues associated with proto-demetalation and β-hydride elimination.
Rapid Mo(CO)6 catalysed one-pot deoxygenation of heterocyclic halo-benzyl alcohols with Lawesson's reagent
Wu, Xiongyu,Mahalingam,Alterman, Mathias
, p. 1501 - 1504 (2007/10/03)
A fast and efficient microwave promoted one-pot method for deoxygenation of heterocyclic halo-benzyl alcohols has been developed. The method does not cause dehalogenation of the substrates and provides the deoxygenated products in high yield after only 30 min.
