74134-61-5

Upstream product

• 26280-46-6 3,6-diphenyl-piperazine-2,5-dione 
• 10025-87-3 trichlorophosphate 
• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 700-63-0 Phenylglycinamid 
• 107378-32-5 2-(2-Oxo-2-phenyl-acetylamino)-2-phenyl-acetamide 

Downstream Products

• 129109-09-7 4-chloro-2,5-diphenylimidazole 
• 129109-04-2 4-chloro-1-cyano-2,5-diphenylimidazole 
• 107378-35-8 2,5-dihydroxy-3,6-diphenylpyrazine 
• 129108-98-1 2-Azido-5-chloro-3,6-diphenylpyrazine 
• 109192-21-4 2,5-Di-hex-1-ynyl-3,6-diphenyl-pyrazine 
• 109192-15-6 2,5-Diphenyl-3,6-bis-phenylethynyl-pyrazine 
• 109192-29-2 3-(5-Chloro-3,6-diphenyl-pyrazin-2-yl)-prop-2-yn-1-ol 
• 109192-28-1 3-[5-(3-Hydroxy-prop-1-ynyl)-3,6-diphenyl-pyrazin-2-yl]-prop-2-yn-1-ol 
• 102027-34-9 2-ethoxy-5-chloro-3,6-diphenyl-pyrazine 
• 107155-26-0 2-chloro-5-methoxy-3,6-diphenyl-pyrazine 

Relevant academic research and scientific papers

Studies on Pyrazines. 14. The Syntheses of 2,5-Dihydroxypyrazines and Their Derivatives

Reaction of phenylglycinamide (1c) with ethyl benzoylformate (2c) in the presence of refluxing ethanolic sodium ethoxide gave 2,5-dihydroxy-3,6-diphenylpyrazine (3i) in 19percent yield.This synthetic method, howewer, was limited to the preparation of 3i.On the other hand, α-aminoamides 1 condensed with α-ketoesters 2 to give the intermediates 5, which were also prepared by condensation of 1 with α-ketalesters 6, followed by hydrolysis of the ketal moeity.Cyclization of 5 with refluxing methanolic sodium methoxide gave only disubstituted 2,5-dihydroxypyrazines 3.Acetylation of 5 with refluxing acetic anhydride/acetic acid led to direct formation of 2,5-diacetoxypyrazines 9.Similarly, compounds 5 could be converted into 2,5-dichloropyrazines 4.