74135-04-9

Usage

Uses

Used in Pharmaceutical Research:
Deproceptin is used as a research tool for studying opioid and cannabinoid receptors. Its interaction with these receptors can provide valuable insights into the development of new drugs targeting these systems, which are involved in pain management, addiction, and other neurological disorders.
Used in Drug Delivery Systems:
Similar to gallotannin, Deproceptin can also be incorporated into drug delivery systems to enhance its bioavailability and therapeutic outcomes. By using carriers such as organic and metallic nanoparticles, the delivery, efficacy, and targeting of Deproceptin can be improved, potentially leading to more effective treatments for various conditions.

Upstream product

• 76658-23-6 Tyr-Pro-OEt hydrochloride 
• 83871-05-0 phenylalanylproline amide hydrochloride 
• 112883-29-1 N-Fmoc-Tyr-OH 
• 71989-31-6 Fmoc-Pro-OH 
• 35661-40-6 N-Fmoc L-Phe 

Relevant academic research and scientific papers

Synthesis of morphiceptin (Tyr-Pro-Phe-Pro-NH2) by dipeptidyl aminopeptidase IV derived from Aspergillus oryzae

Morphiceptin (Tyr-Pro-Phe-Pro-NH2), tetrapeptide, was synthesized using dipeptidyl aminopeptidase IV (DP IV, EC 3.4.14.5) derived from Aspergillus oryzae RIB 915 as a catalyst. Tyr-Pro-OEt was incubated with Phe-Pro-NH2 in the presence of DP IV under various conditions of temperature, concentrations of ethylene glycol, pH, reaction time, and others. Morphiceptin was obtained at 40% yield under the optimal reaction conditions: substrate, 4 mM Tyr-Pro-OEt·HCl and 20 mM Phe-Pro-NH2· HCl; enzyme, DP IV, 0.275 nkat; solvent, 60% ethylene glycol containing 20 mM phosphate buffer at pH 7.0; amine, 4.2 mM diisopropylamine at 4°C for 24 h. Amino group protection was unnecessary for synthesis of morphiceptin by DP IV.

Synthesis, biological evaluation and structural analysis of novel peripherally active morphiceptin analogs

Morphiceptin (Tyr-Pro-Phe-Pro-NH2), a tetrapeptide amide, is a selective ligand of the μ-opioid receptor (MOR). This study reports the synthesis and biological evaluation of a series of novel morphiceptin analogs modified in positions 2 or/and