74151-22-7

Basic information

• Product Name: Quinazoline, 4-chloro-2-methyl-6-nitro-
• CAS NO: 74151-22-7
• Molecular Formula: C9H6ClN3O2
• Molecular Weight: 223.619
• Mol File: 74151-22-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Quinazoline, 4-chloro-2-methyl-6-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinazoline, 4-chloro-2-methyl-6-nitro-(74151-22-7)
• EPA Substance Registry System: Quinazoline, 4-chloro-2-methyl-6-nitro-(74151-22-7)

Safety Data

• Hazardous Substances Data: 74151-22-7(Hazardous Substances Data)

Upstream product

• 3816-62-4 5-nitroanthranilic acid methyl ester 
• 24688-36-6 2-methyl-6-nitroquinazolin-4-ol 
• 24688-36-6 2-methyl-6-nitroquinazolin-4(3H)-one 

Downstream Products

• 74151-28-3 2-(Pentafluorostyryl)-4-(δ-diethylamino-α-methylbutylamino)-6-nitroquinazoline 
• 74151-36-3 2-(2,4,6-Tribromostyryl)-4-(δ-diethylamino-α-methylbutylamino)-6-nitroquinazoline 
• 74151-24-9 2-(2,4,6-Trichlorostyryl)-4-(δ-diethylamino-α-methylbutylamino)-6-nitroquinazoline 
• 74151-26-1 2-(2,4,6-Trichlorostyryl)-4-(δ-diethylamino-α-methylbutylamino)-6-aminoquinazoline 
• 74151-37-4 N⁴-(4-Diethylamino-1-methyl-butyl)-2-[(E)-2-(2,4,6-tribromo-phenyl)-vinyl]-quinazoline-4,6-diamine 

Relevant articles and documents

2-METHYL-QUINAZOLINES

The present invention describes 2-methyl-quinazoline compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions. The 2-methyl substituted quinazoline compounds of general formula(I) effectively and selectively inhibit the Ras-Sos interaction without significantly targeting the EGFR receptor. They are therefore useful for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, such as cancer as a sole agent or in combination with other active ingredients.

COMPOUNDS AND THERAPEUTICAL USE THEREOF

Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.