74152-89-9Relevant academic research and scientific papers
A B2(OH)4-Mediated Synthesis of 2-Substituted Indazolone and Its Application in a DNA-Encoded Library
Bao, Yapeng,Deng, Zongfa,Feng, Jing,Zhu, Weiwei,Li, Jin,Wan, Jinqiao,Liu, Guansai
supporting information, p. 6277 - 6282 (2020/08/24)
Indazolone cores are among the most common structural components in medicinal chemistry and can be found in many biologically active molecules. In this report, a mild and efficient approach to 2-substituted indazolones via B2(OH)4-mediated reductive N-N b
N-N Bond Formation between Primary Amines and Nitrosos: Direct Synthesis of 2-Substituted Indazolones with Mechanistic Insights
Zhu, Jie S.,Kraemer, Niklas,Shatskikh, Marina E.,Li, Clarabella J.,Son, Jung-Ho,Haddadin, Makhluf J.,Tantillo, Dean J.,Kurth, Mark J.
supporting information, p. 4736 - 4739 (2018/08/24)
A concise, one-step route to indazolones from primary alkyl amines and o-nitrobenzyl alcohols is reported. The key step in this readily scalable indazolone forming process involves base-mediated in situ o-nitrobenzyl alcohol → o-nitrosobenzaldehyde conversion. Although this functional group interconversion is known to be useful for 2H-indazole synthesis, its reactivity was modulated for indazolone formation.
Palladium-Catalyzed Carbonylative Cyclization of Azoarenes
Wang, Zechao,Yin, Zhiping,Zhu, Fengxiang,Li, Yahui,Wu, Xiao-Feng
, p. 3637 - 3640 (2017/10/13)
In this communication, we established an interesting palladium-catalyzed carbonylation protocol for the intramolecular cyclization of azoarenes. With Mo(CO)6 as the solid CO source and through C(sp2)?H bond activation, a series of azoarenes were transformed into the corresponding 2-arylindazolones in moderate to good yields. Notably, not only symmetrical azoarenes, but also unsymmetrical substrates underwent the reaction with excellent regioselectivity.
A Convenient Synthesis of 1-Aryl- A nd 2-Aryl-Substituted Indazolones via Intramolecular C-N Coupling Promoted by KO t-Bu
Wang, Wei-Juan,Chen, Jia-Hua,Chen, Zi-Cong,Zeng, Yu-Feng,Zhang, Xue-Jing,Yan, Ming,Chan, Albert S. C.
, p. 3551 - 3558 (2016/10/18)
A new method for the synthesis of 1-arylindazolones and 2-arylindazolones from N′-aryl-2-halobenzohydrazides promoted by KOt-Bu was developed. The difference of 2-halogen substituent exerted a significant effect on the distribution of the products. Two di
A convenient synthesis of 2-arylindazol-3-ones
Bird,Chng,Rama,Saeed
, p. 545 - 548 (2007/10/02)
The reductive cyclisation of o-nitrobenzanilides with zinc and sodium hydroxide in aqueous methanol provides a convenient source of 2-arylindazol-3-ones.
