7416-34-4 Usage
Uses
Used in Pharmaceutical Industry:
3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one is used as an active pharmaceutical ingredient for the treatment of psychotic disturbances. It is particularly effective in cases of chronic and severe schizophrenia, where it helps to reduce spontaneous movements and aggressiveness.
Used in Antipsychotic Applications:
As an antipsychotic agent, 3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one is more active than chlorpromazine, a commonly used antipsychotic. It exhibits a lower sedative effect and fewer side effects compared to more potent neuroleptics, making it a preferred choice for managing psychotic symptoms.
Therapeutic Function
Antipsychotic
Side effects
Molindone hydrochloride, a tetrahydro-indolone derivative, is a neuroleptic agent that is structurally unrelated to
any of the other marketed neuroleptics. Molindone is less potent than haloperidol at blocking D2 receptors;
however, it nonetheless can produce extrapyramidal side effects.
Synthesis
Molindone, 3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-
one (6.4.3), is synthesized by the nitrozation of diethylketone using nitric acid or methylnitrite into nitrozodiethylketone (6.4.1). Reduction of this product with zinc in acetic acid
into 2-aminodiethylketone in the presence of cyclohexandion-1,3 gives 3-ethyl-2-methyl-
4,5,6,7-tetrahydroindol-4-one (6.4.2). Aminomethylation of this product using morpholine
and formaldehyde gives molindone (6.4.3) [51–52].
Metabolism
Metabolism studies in humans show molindone to
be rapidly absorbed and metabolized when given orally. There are 36 recognized metabolites, with less than 2 to
3% unmetabolized molindone being excreted in urine and feces. Clinical studies show that the antipsychotic effects
of molindone last more than 24 hours, suggesting that one or more metabolites may contribute to its activity in vivo
(62).
Check Digit Verification of cas no
The CAS Registry Mumber 7416-34-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,4,1 and 6 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 7416-34:
(6*7)+(5*4)+(4*1)+(3*6)+(2*3)+(1*4)=94
94 % 10 = 4
So 7416-34-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H24N2O2/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18/h12,17H,3-10H2,1-2H3
