741683-10-3Relevant academic research and scientific papers
Compound with alpha substituted phenyl structure as well as preparation method and sterilization agent thereof
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Paragraph 0072-0073, (2019/11/12)
The invention relates to the technical field of sterilization and disinfection materials and in particular to a compound with an alpha substituted phenyl structure as well as a preparation method anda sterilization agent thereof. The compound with the alpha substituted phenyl structure, which is provided by the invention, has a sterilization effect by promoting solidification and denaturation ofproteins of pathogenic microorganisms, particularly has a good killing effect on pathogenic bacteria such as escherichia coli, staphylococcus aureus, pseudomonas aeruginosa and bacillus subtilis variants, in addition has no corrosion function on metals, is free of irritant smell, good in water solubility and green and environment-friendly, can be used as an effective component of sterilization agents and are widely applied to various industries.
Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists
Suzuki, Takao,Moriya, Minoru,Sakamoto, Toshihiro,Suga, Takuya,Kishino, Hiroyuki,Takahashi, Hidekazu,Ishikawa, Makoto,Nagai, Keita,Imai, Yumiko,Sekino, Etsuko,Ito, Masahiko,Iwaasa, Hisashi,Ishihara, Akane,Tokita, Shigeru,Kanatani, Akio,Sato, Nagaaki,Fukami, Takehiro
scheme or table, p. 3072 - 3077 (2010/02/28)
Optimization of high-throughput screening hit 1a led to the identification of a novel spiro-piperidine class of melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. Compound 3c was identified as a highly potent and selective MCH-1R antagonist, which has an IC50 value of 0.09 nM at hMCH-1R. The synthesis and structure-activity relationships of the novel spiro-piperidine MCH-1R antagonists are described.
