741709-58-0

Usage

Uses

Used in Organic Chemistry:
2-Acetylpyridine-4-boronic acid pinacol ester is used as a reagent for the synthesis of various pharmaceuticals, agrochemicals, and materials. Its ability to form covalent bonds with other molecules makes it a useful tool in chemical synthesis.
Used in Drug Discovery:
As a building block in the preparation of new molecules, 2-Acetylpyridine-4-boronic acid pinacol ester is used for developing potential therapeutic applications. Its versatile reactivity allows for the creation of novel compounds with potential benefits in the medical field.
Used in Material Science:
2-Acetylpyridine-4-boronic acid pinacol ester is also utilized in material science for the development of new materials with unique properties. Its role as a building block contributes to the advancement of material technologies.

InChI:InChI=1/C13H18BNO3/c1-9(16)11-8-10(6-7-15-11)14-17-12(2,3)13(4,5)18-14/h6-8H,1-5H3

Upstream product

• 1060805-69-7 1-(4-bromopyridin-2-yl)ethan-1-one 
• 73183-34-3 bis(pinacol)diborane 
• 1122-62-9 2-acetylpyridine 

Relevant academic research and scientific papers

Understanding the Activation of Air-Stable Ir(COD)(Phen)Cl Precatalyst for C-H Borylation of Aromatics and Heteroaromatics

A newly developed robust catalyst [Ir(COD)(Phen)Cl] (A) was used for the C-H borylation of three dozen aromatics and heteroaromatics with excellent yield and selectivity. Activation of the catalyst was identified by the use of catalytic amounts of water, alcohols, etc., when B2pin2 was used in noncoordinating solvents, while for THF catalytic use of HBpin was required. The results were on par with the in situ based expensive system [Ir(OMe)(COD)]2/dtbbpy or Me4Phen.

SREBP INHIBITORS COMPRISING A 6-MEMBERED CENTRAL RING

Provided herein are compounds comprising a three-ring core, such as compounds of Formula (X), Formula (X-A), Formula (X-Ai), Formula (X-B), Formula (X-Bi), Formula (Z), Formula (Z-A), Formula (Z-Ai), Formula (Z-B), Formula (Z-Bi), Formula (I), Formula (I-A), Formula (I-Ai), Formula (I-B), and Formula (I-Bi), and pharmaceutically acceptable salts, solvates, tautomers, isotopes, or isomers thereof. Also provided herein are methods of inhibiting a component of the sterol regulatory element binding protein (SREBP) pathway, such as an SREBP or SREBP cleavage activating protein (SCAP), using these compounds, or pharmaceutically acceptable salts, solvates, tautomers, isotopes, or isomers thereof. Further provided are methods of treating a disorder in a subject in need thereof, such as liver disease, non-alcoholic steatohepatitis, insulin resistance, or cancer.

OXEPINOPYRAZOLE DERIVATIVES AS INHIBITORS OF PI3-KINASE ACTIVITY

The invention is directed to compounds of formula (I), and salts thereof. The compounds are inhibitors of kinase activity, in particular PI3-kinase activity.