741718-76-3Relevant academic research and scientific papers
Synthesis method of chiral trans-2-substituted naphthenic alcohol
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Paragraph 0041-0045; 0086-0089, (2021/09/08)
The invention relates to a synthesis method of chiral trans-2-substituted naphthenic alcohol. The invention provides a method for synthesizing chiral trans-cycloalkanol through asymmetric hydrogenation of palladium-catalyzed 2-substituted cyclic ketone. According to the method,a chiral diphosphine P-P * complex of metal palladium is taken as a catalyst, an acid additive is used in cooperation, asymmetric hydrogenation is carried out on a 2-substituted cyclic ketone compound to obtain a corresponding chiral trans-cycloalkanol compound. the enantiomeric excess of the chiral trans-cycloalkanol compound can reach 97% at most, and the trans-selectivity of the chiral trans-cycloalkanol compound is up to 20: 1. The method is simple and convenient to operate, practical, easy to implement, high in yield, high in atom economy and environment-friendly; the catalyst is commercially available; the reaction conditions are mild; and the method has a potential practical application value.
Palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones for the synthesis oftranscycloalkanols through dynamic kinetic resolution under acidic conditions
Li, Xiang,Zhao, Zi-Biao,Chen, Mu-Wang,Wu, Bo,Wang, Han,Yu, Chang-Bin,Zhou, Yong-Gui
supporting information, p. 5815 - 5818 (2020/06/03)
The first efficient palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones has been described through dynamic kinetic resolution under acidic conditions, providing a facile access to chiraltranscycloalkanol derivatives with excellent enantioselectivities.
Asymmetric hydrogenation of 2-arylated cycloalkanones through dynamic kinetic resolution
Ohkuma, Takeshi,Li, Jing,Noyori, Ryoji
, p. 1383 - 1386 (2007/10/03)
Asymmetric hydrogenation of 2-arylcycloalkanones with trans-RuCl 2(binap)(1,2-diamine) and t-C4H9OK in 2-propanol selectively gives the corresponding cis-2-arylcycloalkanols in excellent enantiomeric purity and high yield.
Regioselectivity in the Catalytic Hydrogenolysis of 7-Fluoro-1-phenylbicycloheptanes
Isogai, Koji,Sakai, Jun-ichi,Kosugi, Katsuhibo
, p. 1349 - 1354 (2007/10/02)
The palladium-catalyzed hydrogenolysis of 7-chloro-7-fluoro-1-phenyl-, 7-fluoro-1-phenyl-, and 7,7-difluoro-1-phenylbicycloheptane was investigated.The hydrogenolysis of the cyclopropane ring occurs at the C1-C6 bond selectively, accompained by the
