741721-03-9

Basic information

• Product Name: 1-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one
• CAS NO: 741721-03-9
• Molecular Weight: 205.213
• Mol File: 741721-03-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one(741721-03-9)
• EPA Substance Registry System: 1-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one(741721-03-9)

Safety Data

• Hazardous Substances Data: 741721-03-9(Hazardous Substances Data)

Upstream product

• 37949-03-4 5,6,8,9-tetrahydrobenzo[7]annulen-7-one 

Relevant articles and documents

Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position

Benzo[7]annulen-7-amines 7 without further polar substituents have been reported as conformationally restricted Ro 25-6981 analogs and show unexpectedly high GluN2B affinity. Herein the corresponding 2-NO2 derivatives 8 were synthesized and pharmacologically evaluated. NO2 derivatives 8 show 5- to 10-fold higher GluN2B affinity than the unsubstituted ligands 7. Docking studies of ligands 7c and 8c reveal an important contribution of the 2-NO2-substituent in determining the binding pose and modulating the GluN2B affinity.

POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS

Polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases