741729-98-6

Basic information

• Product Name: Benzoic acid, 4-(4-piperidinyl)-, ethyl ester
• Synonyms: Benzoic acid, 4-(4-piperidinyl)-, ethyl ester;ETHYL 4-(PIPERIDIN-4-YL)BENZOATE
• CAS NO: 741729-98-6
• Molecular Formula: C₁₄H₁₉NO₂
• Molecular Weight: 233.30616
• Mol File: 741729-98-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzoic acid, 4-(4-piperidinyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(4-piperidinyl)-, ethyl ester(741729-98-6)
• EPA Substance Registry System: Benzoic acid, 4-(4-piperidinyl)-, ethyl ester(741729-98-6)

Safety Data

• Hazardous Substances Data: 741729-98-6(Hazardous Substances Data)

Upstream product

• 206446-48-2 tert-butyl 4-[4-(ethoxycarbonyl)phenyl]piperidine-1-carboxylate 
• 1240969-31-6 4-(4-ethoxycarbonylphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 4334-88-7 p-ethoxycarbonylphenylboronic acid 
• 159503-91-0 tert-butyl 4-bromo-5,6-dihydropyridine-1(2H)-carboxylate 
• 57988-58-6 4-(4-bromophenyl)-4-hydroxy-piperidine 
• 188863-87-8 1-benzyl-4-(4-bromo-phenyl)-1,2,3,6-tetrahydro-pyridine 
• 203661-96-5 ethyl 4-(1-benzyl-1,2,5,6-tetrahydropyridin-4-yl)benzoate 

Downstream Products

• 912947-63-8 4-(1-isopropyl-piperidin-4-yl)-ethyl benzoate 
• 203649-58-5 ethyl 4-[1-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-ylmethyl)piperidin-4-yl]benzoate 

Relevant articles and documents

Design, synthesis, and evaluation of novel and selective G-protein coupled receptor 120 (GPR120) spirocyclic agonists

Type 2 diabetes mellitus (T2DM) is an ever increasing worldwide epidemic, and the identification of safe and effective insulin sensitizers, absent of weight gain, has been a long-standing goal of diabetes research. G-protein coupled receptor 120 (GPR120) has recently emerged as a potential therapeutic target for treating T2DM. Natural occurring, and more recently, synthetic agonists have been associated with insulin sensitizing, anti-inflammatory, and fat metabolism effects. Herein we describe the design, synthesis, and evaluation of a novel spirocyclic GPR120 agonist series, which culminated in the discovery of potent and selective agonist 14. Furthermore, compound 14 was evaluated in vivo and demonstrated acute glucose lowering in an oral glucose tolerance test (oGTT), as well as improvements in homeostatic measurement assessment of insulin resistance (HOMA-IR; a surrogate marker for insulin sensitization) and an increase in glucose infusion rate (GIR) during a hyperinsulinemic euglycemic clamp in diet-induced obese (DIO) mice.

Piperidine carboxylic acid derivatives of 10H-pyrazino[2,3-b][1,4] benzothiazine as orally-active adhesion molecule inhibitors

Novel piperidine carboxylic acid derivatives of 10H-pyrazino[2,3-b][1,4] benzothiazine were prepared and evaluated for their inhibitory activity on the upregulation of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). Replacement of the methanesulfonyl group on the piperidine ring of previously prepared derivatives with a carboxylic acid-containing moiety resulted in a number of potent adhesion molecule inhibitors. Of these, (anti) [3-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)methyl-3-azabicyclo[3.3.1] non-9-yl]acetic acid 2q (ER-49890), showed the most potent oral inhibitory activities against neutrophil migration in an interleukin-1 (IL-1) induced paw inflammation model using mice, and leukocyte accumulation in a carrageenan pleurisy model in the rat, and therapeutic effect on collagen-induced arthritis in rats.