74176-91-3

Basic information

• Product Name: 17α-(m-iodobenzoyloxy)progesterone
• Synonyms: 17α-(m-iodobenzoyloxy)progesterone
• CAS NO: 74176-91-3
• Molecular Weight: 560.472
• Mol File: 74176-91-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 17α-(m-iodobenzoyloxy)progesterone(CAS DataBase Reference)
• NIST Chemistry Reference: 17α-(m-iodobenzoyloxy)progesterone(74176-91-3)
• EPA Substance Registry System: 17α-(m-iodobenzoyloxy)progesterone(74176-91-3)

Safety Data

• Hazardous Substances Data: 74176-91-3(Hazardous Substances Data)

Upstream product

• 68-96-2 17-hydroxyprogesterone 
• 75863-28-4 m-Iodbenzoesaeureanhydrid 

Downstream Products

• 74176-92-4 9α-chloro-17α-(3-iodobenzoyloxy)-4-pregnene-3,20-dione 
• 75863-27-3 3-Iodo-benzoic acid (8S,9R,10S,13S,14S,17R)-17-acetyl-6,9-dichloro-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester 

Relevant articles and documents

Process for preparing 9,11-unsaturated steroidal compound from the corresponding saturated steroidal compound

The present invention provides a non-fermentation process for placing unsaturation at the 9,11 position in a steroidal compound. Also, the present invention provides a process whereby the modified steroidal compound can be separated from the reaction mixture without the use of chromatography. More specifically, the present invention provides a process whereby a steroid compound such as 17-α-hydroxy-progesterone is reacted to form the meta iodoaryl benzoate. The iodoarylbenzoate is then irradiated with visible light in the presence of an alkyl-m-iodobenzoate dichloride to form the 9α-chloro steroid derivative. The chlorinated steroid derivative can then be hydrolized to provide a 9α-chloro steroidal alcohol and m-iodobenzoic acid. The m-iodobenzoic acid is extracted by the use of an aqueous base. The chlorinated steroidal alcohol can then be recovered and converted by conventional dehalogenation techniques to steroidal unsaturated compound having a double bond in the 9,11 position of the steroid nucleus. Alternatively, the chlorinated steroid derivative can be dehalogenation and then hydrolized.