74195-11-2Relevant academic research and scientific papers
I2-Catalyzed N-Sulfonylation of Sulfoximines with Sulfinates in Water at Room Temperature
Zheng, Wenting,Tan, Mingchao,Yang, Lu,Zhou, Lihong,Zeng, Qingle
, p. 1764 - 1768 (2020/03/13)
An oxidative coupling of NH-sulfoximines and arylsulfinates catalyzed by of I2 and H2O2 affords N-sulfonyl sulfoximines. The reaction proceeds under aerobic conditions in water at room temperature. The merits of this proto
Synthetic method of N-aryl sulfone sulfoximine
-
Paragraph 0009-0013; 0054-0057, (2019/12/25)
Sulfoximines have a wide range of applications in organic chemistry, medicinal chemistry, agricultural chemistry, sulfimides are related to the medicinal activity of various organisms, such as antiarrhythmic, antispasmodic, antiasthmatic and antiviral act
Acidities of Sulfoximines and Related Oxosulfonium Cations. Cyclopropyl Effects and Structures of α-Sulfonyl-Type Carbanions
Bordwell, Frederick G.,Branca, John C.,Johnson, Carl R.,Vanier, Noel R.
, p. 3884 - 3889 (2007/10/02)
(Dimethylamino)methylphenyloxosulfonium cation, PhS(O)(NMe2)CH3+, was found to be more acidic than the parent sulfoximine, PhS(O)(NMe)CH3, by about 19 pKa units.The latter is about equal in acidity to PhS(O)CH3 and about 5 pKa units less acidic than PhSO2CH3.The cyclopropyl compounds, c-PrG, with G equal to Ph(NMe2)SO+, p-MeC6H4(NMe2)SO+, F3CSO2, and Ph(PhSO2N)SO, were found to be about 4-7 pKa units less acidic than their acyclic methyl analogues, CH3G.This is interpreted as evidence for a demand on the part of sulfone-type functions for p character in cyclopropyl carbanions.Evidence is presented to show that carbanions of the type GCH2-, where G is an electron-withdrawing function such as RSO2, RS(O)(NR), RSO, Ph2PO, (RO)2PO, and the like, are planar or nearly planar.Acidity data indicate that the preferential generation of chiral, rather than achiral, planar α-sulfonyl carbanions is a consequence of a preferred kinetic pathway rather than an inherent greater thermodynamic stability.Factors controlling the stereoselective generation and reactions of carbanions are reviewed.
