7420-34-0

Upstream product

• 79-19-6 thiosemicarbazide 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 108656-64-0 2-amino-5-(2-bromophenyl)-(1,3,4)-thiadiazole 
• 1414814-55-3 C₁₄H₁₈BrN₃*ClH 
• 1414814-45-1 C₁₅H₁₄BrN₃ 
• 1414814-54-2 C₁₁H₁₂BrN₃O₂ 
• 113111-45-8 2-(2-Bromo-phenyl)-5-chloro-[1,3,4]thiadiazole 

Relevant academic research and scientific papers

The design, synthesis, and: In vitro trypanocidal and leishmanicidal activities of 1,3-thiazole and 4-thiazolidinone ester derivatives

Chagas and leishmaniasis are both neglected tropical diseases, whose inefficient therapies have made them remain the cause for millions of deaths worldwide. Given this, we synthesized 27 novel 1,3-thiazoles and 4-thiazolidinones using bioisosteric and est

Assessment of Thiosemicarbazone-Containing Compounds as Potential Antileukemia Agents against P-gp Overexpressing Drug Resistant K562/A02 Cells

P-Glycoprotein (P-gp) overexpression is considered to be the leading cause of multidrug resistance (MDR) and failure of chemotherapy for leukemia. In this study, seventeen thiosemicarbazone-containing compounds were prepared and evaluated as potential ant

Facile synthesis of novel fluorescent thiazole coumarinyl compounds: Electrochemical, time resolve fluorescence, and solvatochromic study

In this study, Benzocoumarin-Thiazoles-Azomethine derivatives with bioactive scaffolds were synthesized and characterized. The present investigation is concerned with the multistep synthesis of thiazole coumarinyl derivatives (5a-k), which were accomplished from naphthaldehyde, ethyl acetoacetate, and thiosemicarbazide. The formation of newly synthesized derivatives was confirmed by 1H NMR and 13C NMR spectroscopic studies. Thiazole coumarinyl derivatives were subjected to UV-Visible studies in different solvents such as ethanol, ethyl acetate, and DMF for solvatochromic studies. The synthesized coumarinyl thiazole compounds showed absorption in the range of 332-390 nm. Electrochemical studies were performed in DMSO and redox behavior was offered by thiazoles. Fluorescence of coumarinyl thiazole compounds were examined in ethanol, ethyl acetate, and DMF to visualize the solvent effect on the emitting ability of compounds. Fluorescence spectra of coumarinyl thiazoles expressed a sharp emission in the range 436-550 nm.

Iodo-triphenylphosphine · 22, bromobenzaldehyde thiosemicarbazide (I) complex and application thereof

The iodine-triphenylphosphine · 2 2-bromobenzaldehyde thiosemicarbazone thiosemicarbazide (I) complex, has a remarkable inhibition effect on macrophysalurease by the iodo-triphenylphosphine · 2 2-bromobenzaldehyde semicarbazone cuprous 1 complex shown in

Preparation method of iodotriphenylphosphine 2-bromobenzaldehyde thiosemicarbazone cuprous (I) complex

The invention discloses a preparation method of an iodotriphenylphosphine 2-bromobenzaldehyde thiosemicarbazone cuprous (I) complex, which comprises the following steps: S1, dissolving thiosemicarbazone in a hot ethanol/water mixed solvent, slowly and dropwisely adding an ethanol solution of 2-bromobenzaldehyde with the same amount of substance under violent stirring, carrying out heating and refluxing for 4h, carrying out cooling to room temperature to obtain yellow solid, dissolving the obtained solid in absolute ethyl alcohol, and carrying out recrystallizing and purifying to obtain yellowpowder; and S2, dissolving the yellow powder in a hot ethanol/water mixed solvent, adding a mixed solution of a 95% ethanol solution of cuprous iodide and an ethanol solution of triphenylphosphine while stirring, carrying out stirring and heating the solution to 50-60 DEG C, performing reaction for 4h, cooling and filtering the reaction product to obtain yellow clear liquid, standing the clear liquid for 8 days, and separating out faint yellow blocky crystals.

Halogenated aromatic thiosemicarbazones as potent inhibitors of tyrosinase and melanogenesis

A set of 21 halogenated thiosemicarbazones (TSCs) have been synthesized and its inhibitory properties toward activity diphenolase of mushroom tyrosinase and their ability to inhibition of melanogenesis in B16F10 murine, melanoma cell line have been invest

Microwave Assisted Synthesis and Biological Activity of Novel Bis{2-[2-(substituted benzylidene)hydrazinyl]thiazole} Derivatives

Abstract—New 4,4'-(4,6-dimethoxy-1,3-phenylene)bis{2-[2-(substituted benzylidene)hydrazinyl]thiazole} derivatives (5a–5j) have been synthesized from the corresponding 1,1'-(4,6-dimethoxy-1,3-phenylene)bis(2,2- dibromoethanone) and substituted thiosemicarbazones by the conventional method and under microwave irradiation. Structures of the synthesized compounds were characterized by FT-IR, 1H, and 13C NMR and Mass spectra. The products were evaluated for their in vitro antibacterial activity against Gram-positive and Gramnegative stains. Some of the compounds 5b, 5f, 5h demonstrated high activity against B. subtilis (+ve), compound 5c exhibited high activity against E. coli (–ve) and P. aeruginosa (–ve) stains. Among the titled compounds also evaluated for their in vitro antimycobacterial activity, the product 5b demonstrated pronounced antimycobacterial activity against M. bovis stain.

PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles

A highly efficient method for the synthesis of thiadiazole derivatives via intramolecular oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents is developed. The protocol can be carried out smoothly and provides a variety of thiadiazole derivatives in moderate to excellent yields. Graphical Abstract: A highly efficient method for the synthesis of thiadiazole derivatives via PhI-catalyzed intramolecular oxidative coupling of thiosemicarbazide has been developed.

Microwave-assisted synthesis and antitumor evaluation of a new series of thiazolylcoumarin derivatives

A new series of thiazolylcoumarin derivatives was synthesized. The designed strategy embraced a molecular hybridization approach which involves the combination of the thiazole and coumarin pharmacophores together. The new hybrid compounds were tested for

Design, Synthesis, and Evaluation of 3-((4-(t-Butyl)-2-(2-benzylidenehydrazinyl)thiazol-5-yl)methyl)quinolin-2(1H)-ones as Neuraminidase Inhibitors

A series of novel 3-((4-(t-butyl)-2-(2-benzylidenehydrazinyl)thiazol-5-yl)methyl)quinolin-2(1H)-ones (7a-7z) were designed, synthesized and evaluated for their ability of inhibiting neuraminidase (NA) of in?uenza H1N1 virus. Some compounds displayed moder