74201-25-5Relevant articles and documents
Chemical Modification of Peptides Containing γ-Carboxyglutamic Acid
Boggs, Norman T.,Bruton, H. David,Craig, Daniel H.,Helpern, Joseph A.,Marsh, Henry C.,et al.
, p. 1812 - 1816 (2007/10/02)
At acidic pH the γ-proton of the γ-carboxyglutamic acid (Gla) side chain undergoes rapid exchange.We have utilized the reactivity of the resulting enol form to develop a method for the chemical modification of peptide-bound Gla residues.Reaction of Gla pe