742067-56-7Relevant academic research and scientific papers
Discovery of selective and nonpeptidic cathepsin S inhibitors
Irie, Osamu,Ehara, Takeru,Iwasaki, Atsuko,Yokokawa, Fumiaki,Sakaki, Junichi,Hirao, Hajime,Kanazawa, Takanori,Teno, Naoki,Horiuchi, Miyuki,Umemura, Ichiro,Gunji, Hiroki,Masuya, Keiichi,Hitomi, Yuko,Iwasaki, Genji,Nonomura, Kazuhiko,Tanabe, Keiko,Fukaya, Hiroaki,Kosaka, Takatoshi,Snell, Christopher R.,Hallett, Allan
scheme or table, p. 3959 - 3962 (2009/04/06)
Nonpeptidic, selective, and potent cathepsin S inhibitors were derived from an in-house pyrrolopyrimidine cathepsin K inhibitor by modification of the P2 and P3 moieties. The pyrrolopyrimidine-based inhibitors show nanomolar inhibition of cathepsin S with
Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain
Irie, Osamu,Kosaka, Takatoshi,Ehara, Takeru,Yokokawa, Fumiaki,Kanazawa, Takanori,Hirao, Hajime,Iwasaki, Astuko,Sakaki, Junichi,Teno, Naoki,Hitomi, Yuko,Iwasaki, Genji,Fukaya, Hiroaki,Nonomura, Kazuhiko,Tanabe, Keiko,Koizumi, Shinichi,Uchiyama, Noriko,Bevan, Stuart J.,Malcangio, Marzia,Gentry, Clive,Fox, Alyson J.,Yaqoob, Mohammed,Culshaw, Andrew J.,Hallett, Allan
supporting information; scheme or table, p. 5502 - 5505 (2009/08/16)
Cathepsin S inhibitors are well-known to be an attractive target as immunological therapeutic agents. Recently, our gene expression analysis identified that cathepsin S inhibitors could also be effective for neuropathic pain. Herein, we describe the effic
2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF
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Page/Page column 28, (2010/02/08)
The invention relates to pyrrolo pyrimidines of formula (I), wherein Y represents -(CH2)t-O- or -(CH2)r-S-, p is 1 or 2, r is 1, 2 or 3, t is 1, 2 or 3, or Y is -(CH2)j- or -CH=CH-, j is 1 or 2; p is 1 or 2, or Y is -(CH2)f-, f is 1 or 2, p is 1, and the further radicals and symbols have the meaning as defined herein; their preparation, their use as pharmaceuticals, pharmaceutical compositions containing them, the use of such a compound for the manufacture of a pharmaceutical preparation for the treatment of neuropathic pain and to a method for the treatment of such a disease in animals, especially in humans.
