742076-06-8

Basic information

• Product Name: 1-(4-PIPERIDINYL)-2-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE
• Synonyms: 1-(4-PIPERIDINYL)-2-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE;1-(Piperidin-4-yl)-2-(trifluoroMethyl)-1H-benzo[d]iMidazole;1-piperidin-4-yl-2-(trifluoromethyl)benzimidazole;1-(Piperidin-4-yl)
• CAS NO: 742076-06-8
• Molecular Formula: C13H14F3N3
• Molecular Weight: 269.27
• Mol File: 742076-06-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 354.9°C at 760 mmHg
• Flash Point: 168.4°C
• Appearance: /
• Density: 1.41g/cm³
• Vapor Pressure: 3.25E-05mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1-(4-PIPERIDINYL)-2-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-PIPERIDINYL)-2-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE(742076-06-8)
• EPA Substance Registry System: 1-(4-PIPERIDINYL)-2-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE(742076-06-8)

Safety Data

• Hazardous Substances Data: 742076-06-8(Hazardous Substances Data)

Usage

Description

1-(4-PIPERIDINYL)-2-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE is a chemical compound with potential pharmacological properties, belonging to the class of benzimidazole compounds. It features a piperidine ring and a trifluoromethyl group, which may contribute to its enhanced metabolic stability and membrane permeability. 1-(4-PIPERIDINYL)-2-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE has demonstrated potential as an antipsychotic and anxiolytic agent in preclinical studies, primarily through its action as a serotonin receptor agonist, specifically targeting the 5-HT1A receptor, which plays a crucial role in mood and anxiety regulation.

Uses

Used in Pharmaceutical Industry:
1-(4-PIPERIDINYL)-2-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE is used as a potential antipsychotic and anxiolytic agent for the treatment of psychiatric disorders. Its agonistic action on the 5-HT1A receptor suggests its potential in modulating mood and anxiety, offering a new avenue for the development of treatments for conditions such as schizophrenia, bipolar disorder, and anxiety disorders.
Used in Drug Development Research:
In the field of drug development, 1-(4-PIPERIDINYL)-2-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE serves as a promising candidate for further investigation and optimization. Its unique structural features, including the piperidine ring and trifluoromethyl group, may offer advantages in terms of metabolic stability and membrane permeability, which are critical factors in the design of effective pharmaceutical agents. Researchers may explore its potential in the development of new drugs with improved efficacy, safety, and pharmacokinetic profiles for the treatment of various psychiatric conditions.

InChI:InChI=1/C13H14F3N3/c14-13(15,16)12-18-10-3-1-2-4-11(10)19(12)9-5-7-17-8-6-9/h1-4,9,17H,5-8H2