74209-36-2

Usage

Chemical Class

1H-Indazole

Core Structure

1H-Indazole core

Chlorine Substitution

At the third carbon

Methyl Group

At the first carbon

Nitro Group

At the seventh carbon

Molecular Weight

215.62 g/mol

Physical State

Solid

Appearance

Yellow or pale brown crystals

Solubility

Slightly soluble in water, soluble in organic solvents

Melting Point

165-167°C

Boiling Point

Not available as it is a solid

Uses

Commonly used in the pharmaceutical industry for the development of antimicrobial and anti-inflammatory drugs.

Upstream product

• 2942-42-9 7-Nitroindazole 
• 74209-33-9 3-chloro-7-nitro-1H-indazole 
• 74-88-4 methyl iodide 

Downstream Products

• 874297-07-1 N-(3-chloro-1-methyl-1H-indazol-7-yl)-4-methoxy-benzenesulfonamide 

Relevant academic research and scientific papers

Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors

We herein describe a new synthesis of N-(7-indazolyl)benzenesulfonamide derivatives. These compounds were evaluated for their antiproliferative activities toward L1210 murine leukemia cells. One of them, 4-methoxy-N-(3- chloro-7-indazolyl)benzenesulfonamide, was identified as the most potent with an IC50 of 0.44 μM.

New and efficient synthesis of bi- and trisubstituted indazoles

In this paper, the synthesis of bi- and trisubstituted indazoles was described. 4-Alkoxy-7-aminoprotected-indazole or 7-aminoprotected-indazole derivatives were prepared selectively using SnCl2 in alcohol or SnCl2 in ethyl acetate, r