74214-62-3

Basic information

• Product Name: ETHYL BETA-CARBOLINE-3-CARBOXYLATE
• Synonyms: β-cce;β-CCE, Ethyl 9H-pyrido[3,4-b]indole-3-carboxylate;Ro 15-2538;Ethyl b-Carboline-3-carboxylate;Ethyl β-carboline-3-carboxylate (β-CCE);9h-pyrido(3,4-b)indole-3-carboxylicacid,ethylester;BETA-CCE;BETA-CARBOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• CAS NO: 74214-62-3
• Molecular Formula: C₁₄H₁₂N₂O₂
• Molecular Weight: 240.26
• Mol File: 74214-62-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 228-230 °C(lit.)
• Boiling Point: 470.9°C at 760 mmHg
• Flash Point: 238.6°C
• Appearance: /
• Density: 1.308g/cm³
• Vapor Pressure: 4.86E-09mmHg at 25°C
• Refractive Index: 1.698
• Merck: 13,3814
• CAS DataBase Reference: ETHYL BETA-CARBOLINE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL BETA-CARBOLINE-3-CARBOXYLATE(74214-62-3)
• EPA Substance Registry System: ETHYL BETA-CARBOLINE-3-CARBOXYLATE(74214-62-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: RN7092000
• Hazardous Substances Data: 74214-62-3(Hazardous Substances Data)

Usage

General Description

Ethyl beta-carboline-3-carboxylate is a chemical compound that is a derivative of the beta-carboline alkaloid family. It is used in research for its potential neuroprotective and anti-inflammatory properties. Studies have shown that this compound has antioxidant and anti-apoptotic effects, meaning it may have the ability to protect nerve cells from damage and death. Additionally, it has been found to have potential use in the treatment of neurodegenerative diseases such as Parkinson's and Alzheimer's. Ethyl beta-carboline-3-carboxylate shows promise as a therapeutic agent for neurological disorders and is the subject of ongoing research into its potential applications.

InChI:InChI=1/C14H12N2O2/c1-2-18-14(17)12-7-10-9-5-3-4-6-11(9)16-13(10)8-15-12/h3-8,16H,2H2,1H3

Upstream product

• 79185-76-5 ethyl 3,4-dihydro-β-carboline-3-carboxylate 
• 106544-20-1 2-oxo-3-(ethoxycarbonyl)-3,4-dihydro-β-carboline 
• 121994-33-0 (4R,10bR)-2-Phenyl-4,5,10,10b-tetrahydro-3-oxa-1,3a,10-triaza-cyclopenta[a]fluorene-4-carboxylic acid ethyl ester 

Downstream Products

• 752212-92-3 ethyl 9-phenylpropyl-β-carboline-3-carboxylate 
• 65474-79-5 3-hydroxymethyl-β-carboline 
• 78538-75-7 N-(2-phenylethyl)-9H-β-carboline-3-carboxamide 
• 78538-74-6 FG 7142 
• 1400818-31-6 N'-(2-hydroxy-3-methoxybenzlidene)-9-benzyl-β-carboline-3-carbohydrazide 

Relevant articles and documents

1,3-Dipolar Cycloaddition of Nitrones with Nitriles. Scope and Mechanistic Study

1,3-Dipolar cycloadditions of nitrones 1-6 with nitriles 14-16, proceeded under thermal as well as under high pressure conditions with complete regioselectivity to give Δ4-1,2,4-oxadiazolines 17-19.In general, the cycloaddition seemed to be controlled by a HOMO(nitrone)- LUMO(nitrile) interaction.However, a crossover in the orbital control is probable observed with nitrile 16c.Nitrone-nitrile cycloadditions are normal type II cycloadditions so that the nitriles have a U-shaped reactivity curve.Kinetic study on solvent polarity and Hammett equation demonstrated that mechanistically the nitrone-nitrile cycloaddition is consistent with nitrone-alkene cycloaddition.

AROMATIZATION OF 3,4-DIHYDRO-β-CARBOLINE-3-CARBOXYLIC ACID AND ITS DERIVATIVES THROUGH A CARBANION INTERMEDIATE : MECHANISTIC STUDY AND USE IN CHEMICAL SYNTHESIS

3,4-dihydro-β-carboline-3-carboxylic acid, its esters and amide derivatives (AH2) undergo complete aromatization into corresponding β-carboline derivatives (A) by basic treatment under mild conditions.This, together with the easy obtention of 3,4-dihydro-