74214-62-3

Usage

Uses

Used in Pharmaceutical Research:
Ethyl beta-carboline-3-carboxylate is used as a research compound for its potential neuroprotective and anti-inflammatory properties. It is being studied for its antioxidant and anti-apoptotic effects, which may help protect nerve cells from damage and death.
Used in Neurodegenerative Disease Treatment:
Ethyl beta-carboline-3-carboxylate is used as a potential therapeutic agent for the treatment of neurodegenerative diseases such as Parkinson's and Alzheimer's. Its neuroprotective properties are being explored for their potential to slow down or halt the progression of these diseases.
Used in Antioxidant and Anti-apoptotic Applications:
Ethyl beta-carboline-3-carboxylate is used as an antioxidant and anti-apoptotic agent, which may help protect nerve cells from oxidative stress and cell death. This makes it a promising candidate for the development of treatments for various neurological disorders.

InChI:InChI=1/C14H12N2O2/c1-2-18-14(17)12-7-10-9-5-3-4-6-11(9)16-13(10)8-15-12/h3-8,16H,2H2,1H3

Upstream product

• 79185-76-5 ethyl 3,4-dihydro-β-carboline-3-carboxylate 
• 121994-33-0 (4R,10bR)-2-Phenyl-4,5,10,10b-tetrahydro-3-oxa-1,3a,10-triaza-cyclopenta[a]fluorene-4-carboxylic acid ethyl ester 
• 106544-20-1 2-oxo-3-(ethoxycarbonyl)-3,4-dihydro-β-carboline 

Downstream Products

• 118235-12-4 9H-β-Carboline-3-carboxylic acid N'-phenyl-hydrazide 
• 74214-63-4 β-carboline-3-carboxylic acid 
• 126523-76-0 ethyl 9-N-(p-toluenesulfonyl)-β-carboline-3-carboxylate 
• 78538-86-0 3-N-phenyl-β-carboline-3-carboxamide 
• 752212-90-1 ethyl 9-(2',3',4',5',6'-pentafluorobenzyl)-β-carboline-3-carboxylate 
• 126523-79-3 triethyl 11-N-(p-toluenesulfonyl)indolizino<8,7-b>indole-1,2,5-tricarboxylate 
• 126523-78-2 Trifluoro-methanesulfonate3-ethoxycarbonyl-9-(toluene-4-sulfonyl)-2-trimethylsilanylmethyl-9H-β-carbolin-2-ium; 
• 91985-75-0 N-(9H-β-carbolin-3-yl)acetamide 
• 91985-74-9 3-[(methoxycarbonyl)amino]-β-carboline 
• 737817-62-8 ethyl 9-(4-fluorobenzyl)-β-carboline-3-carboxylate 
• 65474-79-5 3-hydroxymethyl-β-carboline 
• 274919-17-4 ethyl 9-(2,5-dichlorobenzyl)-9H-β-carboline-3-carboxylate 
• 78538-74-6 FG 7142 
• 1074712-88-1 9H-β-carboline-3-carboxylic acid pentafluorophenyl ester 

Relevant academic research and scientific papers

1,3-Dipolar Cycloaddition of Nitrones with Nitriles. Scope and Mechanistic Study

1,3-Dipolar cycloadditions of nitrones 1-6 with nitriles 14-16, proceeded under thermal as well as under high pressure conditions with complete regioselectivity to give Δ4-1,2,4-oxadiazolines 17-19.In general, the cycloaddition seemed to be controlled by a HOMO(nitrone)- LUMO(nitrile) interaction.However, a crossover in the orbital control is probable observed with nitrile 16c.Nitrone-nitrile cycloadditions are normal type II cycloadditions so that the nitriles have a U-shaped reactivity curve.Kinetic study on solvent polarity and Hammett equation demonstrated that mechanistically the nitrone-nitrile cycloaddition is consistent with nitrone-alkene cycloaddition.

Employment of Nitriles in the Stereoselective Cycloaddition to Nitrones

The cycloaddition of the nitrones 8-11 to the geminal dinitriles 12a-d has been evaluated.Under thermal as well high-pressure reaction conditions 1,3 dipolar cycloadditions proceed with complete regioselectivity to give the Δ4-1,2,4-oxadiazolin

AROMATIZATION OF 3,4-DIHYDRO-β-CARBOLINE-3-CARBOXYLIC ACID AND ITS DERIVATIVES THROUGH A CARBANION INTERMEDIATE : MECHANISTIC STUDY AND USE IN CHEMICAL SYNTHESIS

3,4-dihydro-β-carboline-3-carboxylic acid, its esters and amide derivatives (AH2) undergo complete aromatization into corresponding β-carboline derivatives (A) by basic treatment under mild conditions.This, together with the easy obtention of 3,4-dihydro-

β-Carbolin-3-carboxylic acid derivatives

A β-carbolin-3-carboxylic acid derivative of the formula STR1 has valuable pharmacological properties when administered to patients, e.g. humans as a drug, have been shown to possess interesting tranquilizing activity.