7422-73-3Relevant academic research and scientific papers
Thio- and Seleno-Dioxaphosphorinane-Constrained Dinucleotides (D-CNA): Synthesis and Conformational Study
Gerland, Béatrice,Addamiano, Claudia,Renard, Brice-Lo?c,Payrastre, Corinne,Gopaul, Deshmukh,Escudier, Jean-Marc
, p. 1450 - 1464 (2017)
Thio- and seleno-α,β- and α,β,γ-D-CNA (constrained nucleic acid) dinucleotides in which two or three torsion angles of the sugar/phosphate backbone are controlled within a dioxaphosphorinane structure have been prepared. Their structural determination was carried out by means of NMR spectroscopy to show only slight variation on the torsion-angle control in comparison with their oxo analogues. Unexpected selenium migration has been pointed out from selenophosphotriester moiety to phosphoramidite group, but this drawback can be overcome using H-phosphonate chemistry.
