7424-56-8

Basic information

• Product Name: 2-(pyridin-3-ylmethylidene)propanedinitrile
• Synonyms: 2-(pyridin-3-ylmethylidene)propanedinitrile;(3-Pyridinylmethylene)malononitrile;2-(3-Pyridinylmethylene)malononitrile;2-(3-Pyridylmethylene)malononitrile
• CAS NO: 7424-56-8
• Molecular Formula: C₉H₅N₃
• Molecular Weight: 0
• Mol File: 7424-56-8.mol
• Article Data: 36

Chemical Properties

• Boiling Point: 317.2°C at 760 mmHg
• Flash Point: 113.9°C
• Appearance: /
• Density: 1.224g/cm³
• Vapor Pressure: 0.000392mmHg at 25°C
• Refractive Index: 1.62
• CAS DataBase Reference: 2-(pyridin-3-ylmethylidene)propanedinitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(pyridin-3-ylmethylidene)propanedinitrile(7424-56-8)
• EPA Substance Registry System: 2-(pyridin-3-ylmethylidene)propanedinitrile(7424-56-8)

Safety Data

• Hazardous Substances Data: 7424-56-8(Hazardous Substances Data)

Usage

General Description

2-(pyridin-3-ylmethylidene)propanedinitrile is a chemical compound with the molecular formula C10H7N3. It is a yellow crystalline solid with a molecular weight of 181.18 g/mol. The compound is used in organic synthesis and as a building block in chemical reactions. It is also a ligand used in coordination chemistry and catalysis. This chemical is considered as a hazardous material and should be handled with caution due to its potential toxicity and environmental impact. Additionally, it is important to follow proper safety protocols and handling procedures when working with this compound.

InChI:InChI=1/C9H5N3/c10-5-9(6-11)4-8-2-1-3-12-7-8/h1-4,7H

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 109-77-3 malononitrile 
• 670-54-2 ethenetetracarbonitrile 

Downstream Products

• 500592-88-1 1-pyridin-3-yl-3-thioxo-2,3,5,6,7,8-hexahydro-isoquinoline-4-carbonitrile 
• 316357-73-0 C₃₁H₂₂ClN₅O₃S₂ 
• 299202-83-8 5-acetyl-2-amino-6-methyl-4-(pyridin-3-yl)-4H-pyran-3-carbonitrile 
• 132813-99-1 6-amino-3-methyl-4-(pyridin-3-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 
• 132664-75-6 (2R,3R,10bS)-3-Benzoyl-2-pyridin-3-yl-2,3-dihydro-10bH-pyrrolo[2,1-a]isoquinoline-1,1-dicarbonitrile 
• 315246-58-3 ethyl 6-amino-5-cyano-2-methyl-4-(pyridin-3-yl)-4H-pyran-3-carboxylate 
• 128462-25-9 ethyl 5-amino-6-cyano-3,4-dihydro-4-oxo-3-phenyl-7-(3-pyridyl)phthalazine-1-carboxylate 
• 136494-54-7 4-Cyclopropyl-2-imino-6-pyridin-3-yl-cyclohex-3-ene-1,1,3-tricarbonitrile 
• 109619-39-8 thioamide of 3-pyridyl-2,4,4-tricyano-3-butenoic acid 
• 125219-61-6 2,6-diamino-4-(3-pyridyl)-3,5-dicyano-4H-thiopyran 
• 109619-37-6 4-Pyridin-3-yl-2-thioxo-1,2,5,6,7,8-hexahydro-quinoline-3-carbonitrile 
• 6293-56-7 3-pyridinylethanol 

Relevant articles and documents

Synthesis and Biological Evaluation of Furo[3,2-c]pyrazole-5-carbimidates

In the present work, novel pyrazole fused dihydrofurans synthesized via a chronological addition of N-chloro succinimide and base piperidine to pyrano[3,2-c]pyrazole carbonitrile derivatives in methanol medium. Oxidative difunctionalization was done with

Photoredox-Catalyzed Addition of Carbamoyl Radicals to Olefins: A 1,4-Dihydropyridine Approach

Functionalization with C1-building blocks are key synthetic methods in organic synthesis. The low reactivity of the most abundant C1-molecule, carbon dioxide, makes alternative carboxylation reactions with CO2-surrogates especially important. We report a photoredox-catalyzed protocol for alkene carbamoylations. Readily accessible 4-carboxamido-Hantzsch esters serve as convenient starting materials that generate carbamoyl radicals upon visible light-mediated single-electron transfer. Addition to various alkenes proceeded with high levels of regio- and chemoselectivity.

Synthesis, in vitro and in silico screening of 2-amino-4-aryl-6-(phenylthio) pyridine-3,5-dicarbonitriles as novel α-glucosidase inhibitors

Inhibition of α-glucosidase enzyme is of prime importance for the treatment of diabetes mellitus (DM). Apart of many organic scaffolds, pyridine based compounds have previously been reported for wide range of bioactivities. The current study reports a series of pyridine based synthetic analogues for their α-glucosidase inhibitory potential assessed by in vitro, kinetics and in silico studies. For this purpose, 2-amino-4-aryl-6-(phenylthio)pyridine-3,5-dicarbonitriles 1–28 were synthesized and subjected to in vitro screening. Several analogs, including 1–3, 7, 9, 11–14, and 16 showed many folds increased inhibitory potential in comparison to the standard acarbose (IC50 = 750 ± 10 μM). Interestingly, compound 7 (IC50 = 55.6 ± 0.3 μM) exhibited thirteen-folds greater inhibition strength than the standard acarbose. Kinetic studies on most potent molecule 7 revealed a competitive type inhibitory mechanism. In silico studies have been performed to examine the binding mode of ligand (compound 7) with the active site residues of α-glucosidase enzyme.