74246-64-3

Usage

Uses

Used in Pharmaceutical Industry:
1,3-Thiazolin-4-one-2-acetonitrile serves as a key building block for the synthesis of a variety of pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications, making it a valuable asset in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 1,3-thiazolin-4-one-2-acetonitrile is utilized as a precursor for the synthesis of various agrochemicals. Its ability to form a range of organic compounds contributes to the development of new pesticides, herbicides, and other agricultural chemicals.
Used in Coordination Chemistry:
1,3-Thiazolin-4-one-2-acetonitrile has the potential to be employed as a ligand in coordination chemistry. Its interaction with metal ions can lead to the formation of coordination compounds with specific properties, useful in various applications such as catalysis and materials science.
Used as a Precursor for Bioactive Molecules:
Due to its reactivity and structural features, 1,3-thiazolin-4-one-2-acetonitrile can act as a precursor for the synthesis of bioactive molecules. These molecules may possess biological activities that can be harnessed in the development of new pharmaceuticals, agrochemicals, or other bioactive compounds.

InChI:InChI=1/C5H4N2OS/c6-2-1-5-7-4(8)3-9-5/h1,3H2

Upstream product

• 68-11-1 mercaptoacetic acid 
• 109-77-3 malononitrile 

Downstream Products

• 74246-66-5 2-(4-oxo-4,5-dihydro-thiazol-2-yl)-3-phenyl-acrylonitrile 
• 74246-68-7 2,4-bis-(4-oxo-4,5-dihydro-thiazol-2-yl)-3-phenyl-pentanedinitrile 
• 86760-31-8 3,6-Dioxo-5-p-tolyl-2,3,6,7-tetrahydro-5H-pyrrolo[3',2':4,5]pyrrolo[2,1-b]thiazole-8-carbonitrile 
• 79421-58-2 5-Amino-6-benzoyl-3-oxo-7-phenyl-2-[1-phenyl-meth-(E)-ylidene]-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-8-carbonitrile 
• 75052-57-2 5-amino-6,8-dicyano-3-oxo-2-(phenylmethylene)-7-phenyl-2,3-dihydro-7H-thiazolo<3,2-a>pyridine 
• 75052-60-7 5-amino-2,3-dihydro-7-(4-chlorophenyl)-2-[(4-chlorophenyl)methylidene]-3-oxo-7H-thiazolo[3,2-a]pyridine-6,8-dicarbonitrile 
• 93032-54-3 (Z)-3-(4-Chloro-phenyl)-2-(4-oxo-4,5-dihydro-thiazol-2-yl)-acrylonitrile 
• 121639-40-5 2-(o-chlorophenylhydrazono cyanomethyl) 5-o-chlorophenylhydrazono 2-thiazolin-4-one 
• 121639-39-2 2-(p-nitrophenylhydrazono cyanomethyl) 5-p-nitrophenylhydrazono 2-thiazolin-4-one 
• 74246-70-1 2-(phenylhydrazono cyanomethyl) 2-thiazolin-4-one 
• 112853-43-7 2-(phenylhydrazono cyanomethyl) 5-phenylhydrazono 2-thiazolin-4-one 
• 112853-44-8 2-(p-tolylhydrazono cyanomethyl) 5-p-tolylhydrazono 2-thiazolin-4-one 
• 112853-45-9 2-(p-chlorophenylhydrazono cyanomethyl) 5-p-chlorophenylhydrazono 2-thiazolin-4-one 
• 121639-41-6 2-(o-tolylhydrazono cyanomethyl) 5-o-tolylhydrazono 2-thiazolin-4-one 

Relevant academic research and scientific papers

Synthesis of some new thiazolo[3,2-a]pyridines and related heterocyclic systems

New 2,7-disubstituted 5-amino-6,8-dicyano-2,3-dihydro-3-oxo thiazolo[3,2-a]pyridines have been prepared. Their cyclization with formamide, nitrous acid and triethylorthoformate afforded a series of polycyclic heterocycles containing condensed pyrimidine and triazine rings. Antifungal tests were also performed. Copyright (C) 2000 Elsevier Science S.A.

Novel synthesis of pyran, thiophene, and pyridine derivatives incorporating thiazole ring and their antitumor evaluation

This study aims to design and synthesize a number of novel pyran, thiophene, and pyridine derivatives incorporating thiazole ring and evaluate their antitumor inhibition (μM) as significant anticancer agents. The reactivity of compound 1 [2-(4-oxo-4,5-dihydrothiazol-2-yl)acetonitrile] towards different chemical reagents was described. Furthermore, the reactivity of all the newly synthesized products was evaluated. The most active compounds towards all the three tumor cancer cell lines used such as MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and SF-268 (CNS cancer), and normal fibroblasts human cell line (WI-38) were compounds 6d, 8, and 10b, which compared with the antiproliferative effects of the reference control doxorubicin. Also, some of the novel compounds indicate higher inhibition than doxorubicin against some of the cancer cell lines used such as 6c (especially towards MCF-7) and 2b, 6b (especially towards SF-268).

Synthesis and Spectroscopic Studies on Some Dyes of the Type Dihydrazono 2-cyanomethyl-2-thiazolin-4-one

Several new dihydrazono-2-thiazolin-4-one dyes 6a-j are synthesized in excellent yields via coupling of 2-cyanomethyl-2-thiazolin-4-one 1 with diazotised aromatic amines in excess pyridine.Proofs of structures based on microanalytical and spectroscopic data are given and discussed.Electronic absorption spectra of the so synthesized dyes are studied in aqueous buffer solutions of varying pH, and their dissociation constants pK are determined spectrophotometrically.