7425-49-2

Basic information

• Product Name: ETHYL 3-BROMOBUTYRATE
• Synonyms: ETHYL 3-BROMOBUTYRATE;ETHYL BETA-BROMOBUTYRATE;3-BROMOBUTYRIC ACID ETHYL ESTER;EINECS 231-059-2;3-Bromo-3-methylpropionic acid ethyl ester;Butanoic acid,3-broMo-, ethyl ester;Ethyl 3-bromobutanoate
• CAS NO: 7425-49-2
• Molecular Formula: C₆H₁₁BrO₂
• Molecular Weight: 195.05
• EINECS: 231-059-2
• Mol File: 7425-49-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 183°C/184
• Flash Point: 90.3 °C
• Appearance: /
• Density: 1.348 g/cm³
• Vapor Pressure: 1.29mmHg at 25°C
• Refractive Index: 1.455
• CAS DataBase Reference: ETHYL 3-BROMOBUTYRATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-BROMOBUTYRATE(7425-49-2)
• EPA Substance Registry System: ETHYL 3-BROMOBUTYRATE(7425-49-2)

Safety Data

• HazardClass: LACHRYMATOR
• Hazardous Substances Data: 7425-49-2(Hazardous Substances Data)

Usage

General Description

Ethyl 3-bromobutyrate, also known as ethyl 3-bromobutanoate, is a chemical compound with the molecular formula C6H11BrO2. It is a colorless liquid with a fruity odor, commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Ethyl 3-bromobutyrate is primarily utilized in the production of fragrance and flavoring agents, as well as in the manufacturing of other chemicals. It is known to be a mild irritant to the skin, eyes, and respiratory system, and should be handled with caution. The compound is also flammable and should be stored and handled in accordance with proper safety measures.

InChI:InChI=1/C6H11BrO2/c1-3-9-6(8)4-5(2)7/h5H,3-4H2,1-2H3

Upstream product

• 5405-41-4 ethyl 3-hydroxybutyrate 
• 64-17-5 ethanol 
• 2623-86-1 3-bromobutyric acid 
• 10544-63-5 ethyl crotonate 
• 623-70-1 ethyl (E)-crotonate 
• 24915-95-5 Ethyl (R)-3-hydroxybutanoate 

Downstream Products

• 626-51-7 3-methyl glutaric acid 
• 6089-12-9 3-bromo-1-butanol 
• 22584-00-5 rac-ethyl 3-cyanobutanoate 
• 10544-63-5 ethyl crotonate 
• 1617-18-1 ethyl 3-butenoate 
• 75321-71-0 3-methyl-4-phenyl-but-3-enoic acid ethyl ester 
• 1356864-62-4 ethyl 4-[[2-(2,6-bis-hydroxymethyl-pyridin-4-yloxy)-ethyl]-(2-nitro-benzenesulfonyl)-amino]-butanoate 
• 1286212-21-2 ethyl 3-(3-((triisopropylsilyl)oxy)cyclohex-2-en-1-yl)butanoate 
• 287392-85-2 4-(4-benzyloxy-phenoxy)-butyric acid ethyl ester 
• 54998-59-3 3-methyl-4-(methyl-phenyl-hydrazono)-butyric acid ethyl ester 
• 116885-98-4 (piperidinyl-1)-4 butanoate d'ethyle 
• 1111179-46-4 ethyl 3-[4-(2-methoxyphenyl)piperazin-1-yl]butanoate 

Relevant articles and documents

Mechanistic Dichotomy of Magnesium- and Zinc-Based Germanium Nucleophiles in the C(sp3)?Ge Cross-Coupling with Alkyl Electrophiles

Robust procedures for two mechanistically distinct C(sp3)?Ge bond formations from alkyl electrophiles and germanium nucleophiles are reported. The germanium reagents were made available as bench-stable solutions by lithium-to-magnesium and lithium-to-zinc transmetalation, respectively. The germanium Grignard reagent reacts with various primary and secondary alkyl electrophiles by an ionic nucleophilic displacement. Conversely, the coupling of the corresponding zinc reagent requires a nickel catalyst, which then engages in radical bond formations with primary, secondary, and even tertiary alkyl bromides. Both methods avoid the regioselectivity issue of alkene hydrogermylation and enable the synthesis of a wide range of functionalized alkyl-substituted germanes.

A NOVEL ONE STEP CONVERSION OF ALCOHOLS INTO ALKYL BROMIDES OR IODIDES

Alcohols are converted in high yields into alkyl bromides or iodides by a one step reaction with N,N'-carbonyldiimidazole and an excess of reactive halides such as allyl bromide or methyl iodide.KEYWORDS - alcohol; N,N'-carbonyldiimidazole; bromination; iodination; 1-alkoxycarbonylimidazole; 1-alkoxycarbonyl-3-substituted imidazolium salt; allyl bromide; methyl iodide