74261-47-5

Basic information

• Product Name: 2-nitro-1-p-tolylpropan-1-one
• Synonyms: 2-nitro-1-p-tolylpropan-1-one
• CAS NO: 74261-47-5
• Molecular Weight: 193.202
• Mol File: 74261-47-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-nitro-1-p-tolylpropan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitro-1-p-tolylpropan-1-one(74261-47-5)
• EPA Substance Registry System: 2-nitro-1-p-tolylpropan-1-one(74261-47-5)

Safety Data

• Hazardous Substances Data: 74261-47-5(Hazardous Substances Data)

Upstream product

• 53982-05-1 2-nitro-1-(p-tolyl)propan-1-ol 
• 5337-93-9 4'-methylpropiophenone 

Downstream Products

• 5337-93-9 4'-methylpropiophenone 

Relevant articles and documents

Metal-free oxidative nitration of α-carbon of carbonyls leads to one-pot synthesis of thiohydroximic acids from acetophenones

A metal-free nitration of the α-C-H to carbonyl in propiophenones was achieved with I2/NaNO2 in the presence of an oxidant in dimethyl sulfoxide (DMSO) as the medium. Conversely under similar conditions, reaction of acetophenones produced thiohydroximic acids via a radical-based cascade event which involves oxidative nitration of the α-carbon to a carbonyl followed by Michael addition of the thiomethyl group from DMSO and subsequent rearrangement. Besides DMSO, the scope of the reaction encompasses other symmetrical and unsymmetrical dialkylsulfoxides.