742699-02-1

Basic information

• Product Name: N-(2-bromobenzyl)-2-iodo-N-((trimethylsilyl)ethynyl)benzamide
• Synonyms: N-(2-bromobenzyl)-2-iodo-N-((trimethylsilyl)ethynyl)benzamide
• CAS NO: 742699-02-1
• Molecular Weight: 512.26
• Mol File: 742699-02-1.mol

Chemical Properties

• CAS DataBase Reference: N-(2-bromobenzyl)-2-iodo-N-((trimethylsilyl)ethynyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-bromobenzyl)-2-iodo-N-((trimethylsilyl)ethynyl)benzamide(742699-02-1)
• EPA Substance Registry System: N-(2-bromobenzyl)-2-iodo-N-((trimethylsilyl)ethynyl)benzamide(742699-02-1)

Safety Data

• Hazardous Substances Data: 742699-02-1(Hazardous Substances Data)

Upstream product

• 136582-33-7 N-(2-bromobenzyl)-2-iodobenzamide 
• 133816-00-9 phenyl(trimethylsilylethynyl)iodonium triflate 
• 3959-05-5 2-bromobenzylamine 
• 88-67-5 2-Iodobenzoic acid 

Downstream Products

• 742699-04-3 N-(2-bromobenzyl)-N-ethynyl-2-iodobenzamide 

Relevant articles and documents

Synthesis of 3-(arylmethylene)isoindolin-1-ones from ynamides by Heck-Suzuki-Miyaura domino reactions. Application to the synthesis of lennoxamine

Substituted 3-(arylmethylene)isoindolin-1-ones can be efficiently synthesized from various ynamides and boronic acids by palladium-catalyzed Heck-Suzuki-Miyaura domino reactions. This methodology has been applied to the total synthesis of lennoxamine and a concise route to this isoindolobenzazepine alkaloid was achieved in eight steps from 2,3-dimethoxybenzoic acid via a key intermediate ynamide.

Heck - Suzuki - Miyaura domino reactions involving ynamides. An efficient access to 3-(arylmethylene)isoindolinones

(Matrix Presented) Substituted 3-(arylmethylene)isoindolin-1-ones can be efficiently synthesized in a stereoselective manner from various ynamides and boronic acids by palladium-catalyzed Heck-Suzuki-Miyaura domino reactions.