742699-16-7Relevant academic research and scientific papers
Enantioselective Alkynylation of Aromatic Aldehydes Catalyzed by a Sterically Highly Demanding Chiral-at-Rhodium Lewis Acid
Luo, Shipeng,Zhang, Xiao,Zheng, Yu,Harms, Klaus,Zhang, Lilu,Meggers, Eric
, p. 8995 - 9005 (2017/09/11)
The enantioselective catalytic alkynylation of aromatic aldehydes is reported using a sterically highly hindered bis-cyclometalated rhodium-based Lewis acid catalyst featuring the octahedral metal as the only stereogenic center. Yields of 58-98% with 79-9
Synthesis and biological evaluation of 3-amino-2-pyrones as selective cyclooxygenase-1 (COX-1) inhibitors
Chu, Xue-Ping,Zhou, Qing-Fa,Zhao, Shen,Ge, Fei-Fei,Fu, Mian,Chen, Jia-Peng,Lu, Tao
, p. 120 - 122 (2013/06/27)
A group of 3-amino-2-pyrones were synthesized and their biological activities were evaluated for inhibiting cyclooxygenase (COX) activity. This study has led to the identification of COX-1-selective inhibitors. Among the tested compounds, the compound 5j exhibited the most potent COX-1 inhibitory activity (IC50 = 19.32 μg/mL) and COX-1 selectivity index (SI = 41.98).
Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors
Rao, P.N. Praveen,Uddin, Md. Jashim,Knaus, Edward E.
, p. 3972 - 3990 (2007/10/03)
A group of regioisomeric 3,4,6-triphenylpyran-2-ones with a MeSO 2 pharmacophore at the paraposition of either a C-3 phenyl or a C-4 phenyl substituent on the central six-membered pyran-2-one ring were prepared and evaluated in vitro for their
