74285-88-4Relevant academic research and scientific papers
Synthesis and biological evaluation of (-)-13,14-dihydroxy-8,11,13-podocarpatrien-7-one and derivatives from (+)-manool
Novoa, María L.,Escalante, Yelisbeth,Maldonado, Liliana,Galindo-Castro, Iván,álvarez, Annamil,Figarella, Katherine,Marsiccobetre, Sabrina,Arocha, Irina,Nieves, Jais,Salazar, Franklin,Gámez, Carlos,Canudas, Nieves,Tropper, Eleonora,González, Teresa,Villamizar, José E.
, p. 207 - 212 (2015)
13,14-Dihydroxy-8,11,13-podocarpatrien-7-one (1) and a series of ring C aromatic diterpene derivatives were synthesised from (+)-manool (4) and evaluated for their cytotoxic, leishmanicidal and trypanocidal activities. Our results indicated that compound 1 and other podocarpane-type intermediates are cytotoxic. Cleavage of C6-C7 bond of compound 7 improved cytotoxic activity, indicating that, in particular, the 6,7-seco-podocarpane-type compound 20 might serve as a lead compound for further development.
