74290-94-1Relevant academic research and scientific papers
Stereochemistry of the Reductive Alkylation of α,β-Epoxy Ketones
McChesney, James D.,Thompson, Thomas N.
, p. 3473 - 3481 (2007/10/02)
α-Epoxy ketones have been found to be useful intermediates for regiospecific alkylation of ketones.We have examined the steric course of the alkylation and shown it to be highly stereoselective.
Optical Rotary Dispersion Studies. 129. Conformational Isotope Effects and Octant Contributions of CD3 and 13CH3 Groups in Cyclohexanone
Lee, Shy-Fuh,Edgar, Mark,Pak, Ghwang Siek,Barth, Guenter,Djerassi, Carl
, p. 4784 - 4790 (2007/10/02)
Through the variable-temperature circular dichroism measurements of (2S)-2-methyl-d3-2-methylcyclohexanone (3) and (2S)-2-methyl-13C-2-methylcyclohexanone (4), quantitative values for the conformational isotope effect are obtained.The chair conformation with the heavier isotope in the equatorial position is found to be energetically preferred by 3.4 and 1.5 cal/mol for 3 and 4, respectively, and empirical force-field calculations qualitatively confirm this view.The CD3 and 13CH3 groups act as weaker octant perturbers compared to CH3.
