7430-49-1Relevant academic research and scientific papers
Copper-catalyzed asymmetric conjugate addition of aryl aluminum reagents to trisubstituted enones: Construction of aryl-substituted quaternary centers
Hawner, Christine,Li, Kangying,Cirriez, Virginie,Alexakis, Alexandre
, p. 8211 - 8214 (2008)
(Chemical Equation Presented) Al be back: Novel aryl and alkenyl aluminum reagents are generated through a halogen/Li exchange-Li/Al transmetalation sequence. These aryl alanes are used in the copper-catalyzed asymmetric conjugate addition reaction to a variety of cyclic enones giving chiral aryl-substituted quaternary centers (see scheme). Both, electron-donating and electron-withdrawing groups give full conversion and very good ee values.
