74302-78-6Relevant academic research and scientific papers
3-(dimethylaminomethyl) cyclohex-4-alcohol derivative as well as preparation method and pharmaceutical application thereof
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, (2021/05/08)
The invention belongs to the field of pharmacy, and relates to a 3-(dimethylaminomethyl) cyclohex-4-alcohol derivative with a general formula (I) or a salt thereof and a preparation method, and relates to an application of the compound in treatment of opioid receptor mediated diseases. The present invention provides a pharmaceutically acceptable solvate or hydrate of a compound of formula (I), and also provides a pharmaceutical composition comprising: a compound of formula (I) or a pharmaceutically acceptable salt, solvate or hydrate thereof; and a pharmaceutically acceptable carrier. The medicine prepared from the compound can be used for treating or improving diseases related to an opioid receptor; wherein the diseases can be selected from but not limited to pain, gastrointestinal diseases and depression.
Sulphur participation in cyclization reactions
Loos, Walter A. J. de,Kuijk, Anne J. W. van den Berg-van,Iersel, Hans M. van,Haan, Jan W. de,Buck, Henk M.
, p. 53 - 57 (2007/10/02)
Cyclization initiated by thiiranium ions was investigated.Cis-fused decalins were formed by a process involving inversion.In nitromethane a sulphonium salt 8 was formed.The reactions of 8 with nucleophilic reagent deviated from those of comparable compoun
