74304-67-9

Upstream product

• 57820-69-6 (3R,4S,5S,6S)-2-bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 67047-07-8 5,6-diacetoxy-7-hydroxyflavone 
• 67047-05-6 4-oxo-2-phenyl-4H-1-benzopyran-5,6,7-triyl triacetate 
• 67047-06-7 7-(benzyloxy)-4-oxo-2-phenyl-4H-1-benzopyran-5,6-diyl diacetate 
• 108-24-7 acetic anhydride 
• 21967-41-9 baicalin 

Downstream Products

• 1374218-49-1 5,6-diacetoxy-8-chloro-7-hydroxyflavon-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester) 
• 1374218-51-5 5,6-diacetoxy-3-bromo-7-hydroxyflavon-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester) 
• 1374218-55-9 6-acetoxy-7-hydroxyflavon-8-nitro-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester) 
• 1374218-57-1 6-acetoxy-7-hydroxyflavon-8-amino-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester) 
• 21967-41-9 baicalin 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 8-substituted and deglucuronidated scutellarin and baicalin analogues as antioxidant responsive element activators

Flavonoids are important bioactive dietary compounds, which are proved to be antioxidant responsive element (ARE) activators to defend against electrophilic toxicants and oxidative stress. The activators induce ARE gene transcription through Nrf2 factor, a major transcriptional stimulator of cytoprotective genes, relieved from a Keap1 complex. In this report, based on the structures of two flavonoids, scutellarin and baicalin, which are extracted from two common Chinese plants Dengzhanhua (Erigeron breviscapus (vant) Hand-Mazz) and Huangqin (Scutellaria baicalensis Georigi), respectively, we synthesized several 8-substituted and deglucuronidated analogues and identified the ARE activation effects of these flavonoids. We found that the Baicalin, deglucurnonidated Baicalin and diaza cyclopenta derivative were more active. Their dose-dependent upregulation activities of ARE and NQO1 and induction effects of Nrf2 were testified. The results presented that these three analogues had good upregulation effects on ARE, and they could be potentially utilized in relieving oxidative stress, upon further neuroprotective tests.

Synthese von Baicalin und einiger anderer Baicalein-glycoside

The 6- and 7-O-β-glucopyranosides 14 and 7 and the 6- and 7-O-β-glucopyranosiduronic acids 18 and 9 of baicalein (1) have been synthesized. 9 was identical with baicalin but 14 and tetuin, further 18 and a "baicalin-6-glucuronide" from Oroxylum indicum were different.