74305-51-4

Basic information

• Product Name: (1Z)-N-hydroxy-1-[4-(2-methylpropyl)phenyl]ethanimine
• CAS NO: 74305-51-4
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.2695
• Mol File: 74305-51-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 298.962°C at 760 mmHg
• Flash Point: 179.385°C
• Density: 0.973g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: (1Z)-N-hydroxy-1-[4-(2-methylpropyl)phenyl]ethanimine(CAS DataBase Reference)
• NIST Chemistry Reference: (1Z)-N-hydroxy-1-[4-(2-methylpropyl)phenyl]ethanimine(74305-51-4)
• EPA Substance Registry System: (1Z)-N-hydroxy-1-[4-(2-methylpropyl)phenyl]ethanimine(74305-51-4)

Safety Data

• Hazardous Substances Data: 74305-51-4(Hazardous Substances Data)

Upstream product

• 53648-05-8 ibuproxam 
• 38861-78-8 1-(4-isobutyl-phenyl)-ethanone 

Downstream Products

• 20331-32-2 N-<4-(2-methylpropyl)phenyl>acetamide 
• 1462328-04-6 1-(4-isobutylphenyl)ethan-1-one O-acetyl oxime 
• 1462327-93-0 dimethyl 5-(4-isobutylphenyl)-1H-pyrrole-2,3-dicarboxylate 
• 38861-78-8 1-(4-isobutyl-phenyl)-ethanone 
• 111525-01-0 1-(4-(2'-methylpropyl)phenyl)ethyl hydroxylamine 
• 164579-51-5 4-(2-methylpropyl)phenylethylamine 
• 111525-05-4 N-Acetoxy-N-[1-(4-isobutyl-phenyl)-ethyl]-acetamide 

Relevant articles and documents

Copper(0)/PPh3-Mediated Bisheteroannulations of o-Nitroalkynes with Methylketoximes Accessing Pyrazo-Fused Pseudoindoxyls

A copper(0)/PPh3-mediated cascade bisheteroannulation reaction of o-nitroalkynes with methylketoximes has been developed that provides viable access to a diverse range of pyrazo-fused pseudoindoxyl compounds. Synthetically useful functional groups including sensitive C-I bonds are compatible with this system. Mechanistic studies suggest a reaction cascade involving sequential PPh3-mediated deoxygenative cycloisomerization and copper-catalyzed [3 + 2] pyrazo-annulation.

Copper-Catalyzed Three-Component Domino Cyclization for the Synthesis of 4-Aryl-5-(arythio)-2-(trifluoromethyl)oxazoles

A copper-catalyzed oxidative cyclization of oxime, arylthiol, and trifluoroacetic anhydride for the construction of trisubstituted oxazoles has been developed. This transformation combines N-O bond cleavage, C-H functionalization, and intramolecular annulation, providing a practical protocol for the introduction of a trifluoromethyl (-CF3) group at oxazole rings.

Elemental tellurium mediated synthesis of 2-(trifluoromethyl)oxazoles using trifluoroacetic anhydride as reagent

An elemental tellurium mediated synthesis of 2-(trifluoromethyl)oxazoles from the reaction of acetophenone oxime acetates with trifluoroacetic anhydride has been developed. This new tandem cyclization proceeds in good to excellent yields via a SET reduction followed by a 5-endo-trig pathway. Some of the title compounds showed fungicidal and insecticidal activities.

Palladium-Catalyzed C-H Functionalization of Aromatic Oximes: A Strategy for the Synthesis of Isoquinolines

An efficient strategy for synthesis of isoquinolines via Pd(II)-catalyzed cyclization reaction of oximes with vinyl azides or homocoupling of oximes is reported. Oximes could serve as a directing group and an internal oxidant in the transformation. This reaction features good functional group tolerance and provides a useful protocol for the synthesis of different kinds of isoquinolines under mild conditions. Some control experiments and 15N isotope labeling experiments were conducted for the mechanistic research. (Chemical Equation Presented).

APPLICATIONS OF N6-SUBSTITUTED ADENOSINE DERIVATIVE AND N6-SUBSTITUTED ADENINE DERIVATIVE TO CALMING, HYPNOSES, CONVULSION RESISTANCE, EPILEPTIC RESISTANCE, PARKINSON DISEASE RESISTANCE, AND DEMENTIA PREVENTION AND TREATMENT

PROBLEM TO BE SOLVED: To prepare analgesics, hypnotic agents, anticonvulsant agents, antiepileptics, antiparkinson drugs, dementia prophylactics, and health care food. SOLUTION: The present invention relates to an N6-substituted adenosine derivative and an N6-substituted adenine derivative selected from the group consisting of specific compounds. The present invention also relates to a pharmaceutical composition at least comprising a therapeutically effective amount of the compounds and a pharmaceutically acceptable carrier. The invention further relates to the compounds used in preparation of analgesics, hypnotic agents, anticonvulsant agents, antiepileptics, antiparkinson drugs, dementia prophylactics, and health care food. COPYRIGHT: (C)2016,JPO&INPIT

N6-SUBSTITUTED ADENOSINE DERIVATIVES AND N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF

The present invention provides N6-substituted adenosine derivatives and N6-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.

N6-SUBSTITUTED ADENOSINE DERIVATIVES, N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF

The present invention provides N6-substituted adenosine derivatives and N6-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.