7432-44-2 Usage
Uses
Used in Pharmaceutical Industry:
Methyl (3alpha,5beta,7alpha,12alpha)-7-acetoxy-3,12-dihydroxycholan-24-oate serves as a drug or drug intermediate due to its potential therapeutic effects on conditions related to bile acid metabolism and liver function. Its specific molecular structure allows for targeted interactions with biological systems, making it a promising candidate for the development of new medications.
Used in Research and Development:
In the scientific community, methyl (3alpha,5beta,7alpha,12alpha)-7-acetoxy-3,12-dihydroxycholan-24-oate is utilized as a valuable tool in research aimed at understanding and modulating bile acid metabolism. Its unique properties and structural features provide insights into the mechanisms of action and potential therapeutic applications in liver-related diseases and disorders.
Used in Drug Delivery Systems:
Similar to other complex steroidal compounds, methyl (3alpha,5beta,7alpha,12alpha)-7-acetoxy-3,12-dihydroxycholan-24-oate may be incorporated into drug delivery systems to enhance its bioavailability and therapeutic efficacy. This could involve encapsulation in nanoparticles or other carriers to improve its solubility, stability, and targeted delivery to specific tissues or organs.
Check Digit Verification of cas no
The CAS Registry Mumber 7432-44-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,4,3 and 2 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 7432-44:
(6*7)+(5*4)+(4*3)+(3*2)+(2*4)+(1*4)=92
92 % 10 = 2
So 7432-44-2 is a valid CAS Registry Number.
7432-44-2Relevant articles and documents
Steroidal guanidines as enantioselective receptors for N-acyl α-amino acids. Part 1. 3α-Guanylated carbamates derived from cholic acid
Lawless,Blackburn,Ayling,Perez-Payan,Davis
, p. 1329 - 1341 (2007/10/03)
Receptors 5-11, bearing guanidinium, carbamate and (in some cases) other functional groups, were synthesized from cholic acid 1. These cations were shown to extract chiral carboxylate anions from aqueous buffer into chloroform with significant enantioselectivities. The most successful receptors bore two carbamate substituents and achieved, in the best cases, ratios (L:D) of 7-10:1 for a series of five N-acetyl α-amino acids.
New Procedures for Selectively Protected Cholic Acid Derivatives. Regioselective Protection of the 12α-OH Group, and t-Butyl Esterfication of the Carboxyl Group
Bonar-Law, Richard P.,Davis, Anthony P.,Sanders, Jeremy K. M.
, p. 2245 - 2250 (2007/10/02)
Effective procedures have been developed for the preparation of various selectively protected cholic acid derivatives.Treatment of cholic acid or methyl cholate with trifluoroacetic anhydride in THF, followed by partial deacylation under acidic conditions, leads to the 12α-trifluoroacetates (10a) and (10m), respectively.Trifluoroacetic anhydride may also be used as a condensing agent in the synthesis of t-butyl cholates.Particularly notable is the preparation of the ester (10b), which incorporates both these developments and is arguably the most efficient method yet for differentiating between positions 7 and 12 in the cholic acid nucleus.
