7433-46-7

Usage

Type of compound

Organic

Functional groups

Hydroxyl group, methyl group, urea molecule

Uses

+ Reactant in organic synthesis
+ Building block in pharmaceutical and agrochemical production
+ Stabilizer
+ Formulation of personal care products

Properties

+ Water-soluble
+ Ability to form stable complexes with metal ions
+ Relative stability under normal conditions

InChI:InChI=1/C2H6N2O2/c1-3-2(5)4-6/h6H,1H3,(H2,3,4,5)

Upstream product

• 624-83-9 methyl isocyanate 
• 127-06-0 acetone oxime 
• 84816-15-9 Z-C-phenyl N-(4-chlorophenylcarbamoyl) nitrone 

Downstream Products

• 110795-02-3 1-Hydroxy-3-methyl-6-phenyl-1H-pyrimidine-2,4-dione 
• 104308-37-4 3-(N-methylcarbamoyl)-2-oxa-3-azabicyclo-<2.2.1>hept-5-ene 
• 63216-35-3 N-Hydroxy-N(Tosylmethyl) N'Methylureid 

Relevant academic research and scientific papers

MECHANISM OF THE CARBAMOYLATION OF OXIMES

N-Acylnitrones are formed initially during the cabamoylation of oximes of the aldehydes and ketone series.Depending on the structure of the initial compounds they can then either rearrange to O-carbamoylated oximes or undergo decomposition to N-hydroxyureas and the corresponding aldehydes and ketones.In some cases isomerization of the oximes is observed under the influence of isocyanate.

Action des hydroxyurees sur les maleate et fumarate de methyle. Obtention des carbomethoxy-5 oxa-6 dihydrouraciles; transposition en carbomethoxymethylene-5 hydantoines

We describe in this paper the Michael-type addition of hydroxyureas with methyl maleate and fumarate.The cyclization of the ureidoxyester intermediates obtained leads to the isolation of 5-carbomethoxy 6-oxadihydrouracils; their structure is proved by X-ray analysis.These relatively unstable compounds undergo transposition under basic conditions and give 5-carbomethoxyhydantoins.