743423-46-3Relevant academic research and scientific papers
Synthesis of 310-helix-inducing constrained analogues of L-proline
Hanessian, Stephen,Papeo, Gianluca,Fettis, Kamal,Therrien, Eric,Viet, Minh Tan Phan
, p. 4891 - 4899 (2004)
A bicyclic indolizidinone carboxylic acid and a tricyclic constrained analogue of L-proline were synthesized and evaluated for their ability to induce helix formation as L-Ala tetrapeptides. Variable-temperature NMR, DMSO titration, CD spectra, and X-ray structure analyses, in conjunction with molecular modeling, confirmed the existence of 310-helical motifs with di- and tetrapeptides of L-Ala.
