743423-61-2Relevant academic research and scientific papers
Synthesis of bidesmosidic dihydrodiosgenin saponins bearing a 3-O-β-chacotriosyl moiety
Zhang, Yichun,Li, Yingxia,Zhu, Shilei,Guan, Huashi,Lin, Feng,Yu, Biao
, p. 1753 - 1759 (2007/10/03)
3-O-β-Chacotriosyl-26-O-β-D-glucopyranosyl-(25R)-furost-5-en (1), a mimic of the antitumor active proto-dioscin, was concisely synthesized from diosgenin in a linear nine steps and in 17% overall yield. Its congeners with a α-L-rhamnopyranosyl, β-lactosyl, or without a substituent at the 26-OH (13-15) were also prepared. Compound 1, as well as 13-15, did not show any inhibition against tumor cells, implying that proto-dioscin might be also inactive, but readily converted into the antitumor active dioscin.
