743442-80-0

Basic information

• Product Name: t-butyl (2S,4R)-5-[N',N''-bis(benzyloxycarbonyl)guanidino]-2-N-(9-phenyl-9H-fluoren-9-yl)amino-4-N-(2-trimethylsilylethanesulfonyl)aminopentanoate
• Synonyms: t-butyl (2S,4R)-5-[N',N''-bis(benzyloxycarbonyl)guanidino]-2-N-(9-phenyl-9H-fluoren-9-yl)amino-4-N-(2-trimethylsilylethanesulfonyl)aminopentanoate
• CAS NO: 743442-80-0
• Molecular Weight: 918.199
• Mol File: 743442-80-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: t-butyl (2S,4R)-5-[N',N''-bis(benzyloxycarbonyl)guanidino]-2-N-(9-phenyl-9H-fluoren-9-yl)amino-4-N-(2-trimethylsilylethanesulfonyl)aminopentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: t-butyl (2S,4R)-5-[N',N''-bis(benzyloxycarbonyl)guanidino]-2-N-(9-phenyl-9H-fluoren-9-yl)amino-4-N-(2-trimethylsilylethanesulfonyl)aminopentanoate(743442-80-0)
• EPA Substance Registry System: t-butyl (2S,4R)-5-[N',N''-bis(benzyloxycarbonyl)guanidino]-2-N-(9-phenyl-9H-fluoren-9-yl)amino-4-N-(2-trimethylsilylethanesulfonyl)aminopentanoate(743442-80-0)

Safety Data

• Hazardous Substances Data: 743442-80-0(Hazardous Substances Data)

Upstream product

• 25508-20-7 N,N'-dibenzyloxycarbonyl-(S)-methyl-isothiourea 
• 16338-48-0 L-allylglycine 
• 743442-79-7 t-butyl (2S,4R)-5-azido-2-N-(9-phenyl-9H-fluoren-9-yl)amino-4-N-(2-trimethylsilylethanesulfonyl)aminopentanoate 
• 659726-50-8 tert-butyl (2S)-2-[N-(9-phenylfluoren-9-yl)amino]pent-4-enoate 
• 323196-01-6 N-phenylfluorenyl-(S)-2-amino-4-pentenoic acid 
• 135722-56-4 ethyl (RS)-N-(tert-butoxycarbonyl)-2-aminopent-4-enoate 
• 90600-20-7 (2S)-2-[(tert-butoxycarbonyl)amino]pent-4-enoic acid 
• 55135-66-5 9-bromo-9-phenyl-9H-fluorene 

Relevant articles and documents

Iminoiodane mediated aziridination of α-allylglycine: Access to a novel rigid arginine derivative and to the natural amino acid enduracididine

The synthesis of fully protected aminodihydrohistidines in optically pure form is described starting from allylglycine derivatives. These compounds represent novel conformationally constrained analogues of arginine, one of them being, in addition, a protected form of the marine natural product, enduracididine. The key step of the strategy is a one-pot copper-catalyzed aziridination of t-butyl (S)-N-(9-phenyl-9H-fluoren-9-yl)allylglycinate ((S)-16) with 2-trimethylsilylethanesulfonamide in the presence of iodosylbenzene.