74359-96-9Relevant academic research and scientific papers
ANTI-FIBROTIC PYRIDINONES
-
Paragraph 1141, (2015/11/02)
This application relates to polycyclic compounds with a pyridinone or pyridinone derivative core including, substituted pyridinones, 5,6- and 6,6- bicyclic heterocycles and substituted pyridine-thiones. This application also discloses methods of preparing these polycyclic compounds, pharmaceutical compositions and medicaments comprising said compounds and methods to treat, prevent or diagnose diseases, disorders or conditions associated with fibrosis.
COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS
-
Page/Page column 86, (2009/12/28)
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.
Controlled Reduction of Pyrimidin(e)-2(1H)-ones and -thiones with Metal Hydride Complexes. Regioselective Preparation of Dihydro- and Tetrahydro-pyrimidin-2(1H)-ones and the Corresponding Thiones
Kashima, Choji,Katoh, Akira,Yokota, Yuko,Omote, Yoshimori
, p. 1622 - 1625 (2007/10/02)
1,4,6-Trisubstituted pyrimidin-2(1H)-ones were easily reduced with sodium borohydride to give mixtures of 3-aryl-3,4-dihydro-, 1-aryl-3,4-dihydro-, and 3,4,5,6-tetrahydro-pyrimidin-2(1H)-ones.The ratio of the three products was dramatically dependent on t
