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Ent-16α,17-Dihydroxy-19-kauranoic acid is a naturally occurring diterpene compound found in plants of the genus Isodon. It has been recognized for its potential as an anti-inflammatory and anticancer agent, exhibiting significant activity in inhibiting the proliferation of cancer cells. Additionally, ent-16α,17-Dihydroxy-19-kauranoic acid has demonstrated antioxidant and neuroprotective properties, which contribute to its interest for potential therapeutic applications. Its unique structure and bioactivity position it as a valuable target for further research in drug development and pharmacological studies.

74365-74-5

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74365-74-5 Usage

Uses

Used in Pharmaceutical Industry:
Ent-16α,17-Dihydroxy-19-kauranoic acid is used as an anti-inflammatory agent for its potential to reduce inflammation and alleviate symptoms associated with inflammatory conditions.
Used in Oncology:
Ent-16α,17-Dihydroxy-19-kauranoic acid is used as an anticancer agent for its ability to inhibit the proliferation of cancer cells, making it a promising candidate for the development of new cancer treatments.
Used in Neuroprotection:
Ent-16α,17-Dihydroxy-19-kauranoic acid is used as a neuroprotective agent for its potential to protect neurons from damage and degeneration, which could be beneficial in the treatment of neurodegenerative diseases.
Used in Antioxidant Formulations:
Ent-16α,17-Dihydroxy-19-kauranoic acid is used as an antioxidant in formulations designed to combat oxidative stress and protect cells from damage caused by reactive oxygen species.

Check Digit Verification of cas no

The CAS Registry Mumber 74365-74-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,3,6 and 5 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 74365-74:
(7*7)+(6*4)+(5*3)+(4*6)+(3*5)+(2*7)+(1*4)=145
145 % 10 = 5
So 74365-74-5 is a valid CAS Registry Number.

74365-74-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 16β,17-dihydroxy-ent-kauran-19-oic acid

1.2 Other means of identification

Product number -
Other names 16β,17-Dihydroxy-(-)-kauran-19-oic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:74365-74-5 SDS

74365-74-5Downstream Products

74365-74-5Relevant academic research and scientific papers

KAURANE DITERPENOIDS FROM ASTER AGERATOIDES

Cheng, Dong-Liang,Cao, Xiao-Ping,Wei, Han-Xun,He. Lan

, p. 1181 - 1184 (1993)

Two new natural diterpene glycosides, as well as their aglycone, whose structure were elucidated by means of spectral and chemical methods as 16β,17-dihydroxy-(-)-kauran-19-oic acid-β-D-glucopyranosyl ester and 16β-hydroxy-17-acetoxy-(-)-kauran-19-oic acid-β-D-glucopyranosyl ester, have been isolated from the aerial parts of Aster ageratoides. Key words: Aster ageratoides; Compositae; ent-kaurane-type diterpenoids; glycosides; 16β,17-dihydroxy-(-)-kauran-19-oic acid-β-D-glucopyranosyl ester; 16β-hydroxy-17-acetoxy-(-)-kauran-19-oic acid-β-D-glucopyranosyl ester.

NMR Assignments and Absolute Configuration of Kauranoids

Tan, R. X.,Wang, W. Z.,Wu, S. X.,Yang, L.

, p. 749 - 754 (1995)

A new ent-kaurane diterpenoid glycoside has been shown to be the main sweetening constituent of the traditional medicines Aster tongolensis and A. ageratoides native to China.This study involved the total 1H and 13C spectral assignment of the compound and its degraded product by means of two-dimensional NMR techniques (COSY, NOESY, HETCOR and TOCSY) and resulted in unambiguous spectral assignments, particularly in the heavily convoluted regions of the spectra.Concerning the absolute stereochemistry, the sweetener was determined to be (4R,5S,8S,9S,10S,13R)-16,17-dihydroxykauran-19-oic acid β-D-glucopyranosyl ester through a combination of circular dichroism and 2D NMR techniques. - Keywords: NMR; 13C NMR; 1H NMR; kaurane diterpenoid; absolute configuration

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