74367-78-5

Usage

Uses

Used in Organic Synthesis:
3,5-Dinitrobenzyl chloride is used as a reagent in the synthesis of various organic compounds. Its reactivity allows it to form new chemical bonds and create a wide range of products.
Used in the Synthesis of Double-Spanned Double-Cavity Calix[4]arenes:
In the field of supramolecular chemistry, 3,5-dinitrobenzyl chloride is used as a key component in the synthesis of double-spanned double-cavity calix[4]arenes. These calix[4]arenes have unique structural features and potential applications in host-guest chemistry and molecular recognition.
Used in the Synthesis of 3,5-Dinitrobenzylamines:
3,5-Dinitrobenzyl chloride is also used in the synthesis of 3,5-dinitrobenzylamines, which are important intermediates in the production of various pharmaceuticals and agrochemicals.
Used in Fluorescence Flow Immunoassay:
In analytical chemistry, 3,5-dinitrobenzyl chloride is utilized in the development of fluorescence flow immunoassay methods for the determination of 4-nitrophenol. This application takes advantage of the compound's fluorescent properties to detect and quantify target analytes in complex samples.

InChI:InChI=1/C7H5ClN2O4/c8-4-5-1-6(9(11)12)3-7(2-5)10(13)14/h1-3H,4H2

Upstream product

• 71022-43-0 3,5-dinitrobenzyl alcohol 
• 99-34-3 3,5-dinitrobenzoic acid 
• 75-62-7 Bromotrichloromethane 
• 618-85-9 3,5-dinitrotoluene 

Downstream Products

• 71022-43-0 3,5-dinitrobenzyl alcohol 
• 78710-94-8 Phosphoric acid mono-{(2R,3S,4R,5R)-5-[6-amino-8-(3,5-dinitro-benzylsulfanyl)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl} ester 
• 148319-72-6 Benzaldehyde (4,6-dimethylpyrimidin-2-yl)(3,5-dinitrobenzyl)hydrazone 
• 444343-45-7 N-(3,5-dinitrobenzyl)phthalimide 
• 252358-63-7 1-(3,5-Dinitrobenzyl)-2,3,3-trimethylindolium iodide 
• 1021465-71-3 C₂₅H₂₀N₂O₄P⁽¹⁺⁾*Cl^(1-) 

Relevant academic research and scientific papers

Preparation method of tazobactam

The invention discloses a preparation method of tazobactam. The method includes: adopting 3, 5-dinitrobenzyl chloride as the carboxyl protection reagent for esterification reaction with 6alpha-bromopenam-3alpha-carboxylic acid-1beta-oxide; then carrying out reduction, thermal cracking, chloromethylation, azidation, double oxidation and cyclization addition to obtain tazobactam3, 5-dinitrobenzyl ester; then taking palladium carbon as the catalyst, and employing hydrogen to remove the protection of tazobactam3, 5-dinitrobenzyl ester so as to obtain tazobactam; and reacting the by-product 3, 5-dinitrotoluene with the chlorinating reagent N-chlorosuccinimide to prepare 3, 5-dinitrobenzyl chloride, thus realizing recycling of the protection reagent. The method provided by the invention uses 3,5-dinitrobenzyl chloride with stable chemical properties, high reaction activity and low price as the carboxyl protection reagent, avoids the use of peracetic acid that has poor stability and easily causes decomposition explosion, and realizes intrinsic safety of the process.

Derivatives of 1H-imidazole-4,5-dicarboxamide and Use Thereof in Preparation of Anticoccidial Drugs

Disclosed are derivatives of 1H-imidazole-4,5-dicarboxamide and use thereof in preparation of anticoccidial drugs. The derivatives have structural formulae as shown in formulae (I) to (VI). The derivatives of 1H-imidazole-4,5-dicarboxamide as disclosed in the present invention have significant anticoccidial effect, especially against coccidia that show a resistance to other anticoccidial drugs, and thus they can be used in preparation of anticoccidial drug.

The use of bromotrichloromethane in chlorination reactions

Carbon tetrachloride is no longer used as a common solvent due to its toxicity and harmful environmental impact. The synthesis of gem-dichloroalkenes from aldehydes by using triphenylphosphine typically requires carbon tetrachloride as a solvent. We report that stoichiometric bromotrichloromethane in acetonitrile can be used in place of solvent quantities of carbon tetrachloride in this transformation. Similarly, bromotrichloromethane in dichloromethane can be used for the room-temperature Appel reaction of benzyl alcohols to form benzyl chlorides, which is commonly carried out in refluxing carbon tetrachloride. Georg Thieme Verlag Stuttgart New York.

Pentiptycene-derived light-driven molecular brakes: Substituent effects of the brake component

Five pentiptycene-derived stilbene systems (1R; R = H, OM, NO, Pr, and Bu) have been prepared and investigated as light-driven molecular brakes that have different-sized brake components (1Hrot = 108-109 s-1) with little interaction with the brake component in the trans form ((E)-1R), which corresponds to the brake-off state. When the brake is turned on by photoisomerization to the cis form ((Z)-1R), the pentiptycene rotation can be arrested on the NMR spectroscopic timescale at temperatures that depend on the brake component. In the cases of (Z)-1NO, (Z)-1Pr, and (Z)-1Bu, the rotation is nearly blocked (krot = 2-6 s-1) at 298 K. It is also demonstrated that the rotation is slower in [D6]DMSO than in CD2Cl 2. A linear relationship between the free energies of the rotational barrier and the steric parameter A values is present only for (Z)-1H, (Z)-1OM, and (Z)-1NO, and it levels off on going from (Z)-1NO to (Z)-1Pr and (Z)-1Bu. DFT calculations provide insights into the substituent effects in the rotational ground and transition states. The molar reversibility of the E-Z photoswitching is up to 46%, and both the E and Z isomers are stable under the irradiation conditions.

A pentiptycene-derived light-driven molecular brake

(Chemical Equation Presented) A room-temperature light-driven molecular brake (1), consisting of a pentiptycene rotator, a 3,5-dinitrophenyl brake, and a photoisomerizable ethenyl spacer, is reported. The rotation rates of the rotator differ by about 9 orders of magnitude between the brake-on (cis-1) and brake-off (trans-1) states.