74385-21-0Relevant academic research and scientific papers
Thermolabile Hydrocarbons, XX. Synthesis, Structure, and Strain of Sym. Tetraalkyl-1,2-diarylethanes
Kratt, Guenter,Beckhaus, Hans-Dieter,Lindner, Hans Joerg,Ruechardt, Christoph
, p. 3235 - 3263 (2007/10/02)
The syntheses of 18 1,1,2,2-tetraalkyl-1,2-diarylethanes 1 - 4 by dimerisation procedures starting with 10 - 13 are reported.In the absence of p-substituents X and with increasing alkyl side chains the α,p-dimers 6 or their aromatic counter parts 7 are obtained besides or instead of 1.The relationships between strain enthalpy Hs, bond lengths, bond angles, torsional angles, and rotational barrier are discussed on the basis of force field calculations.They are supported by two additional experimental structure determinations by X-ray diffraction.
Antiestrogens. Synthesis and Evaluation of Mammary Tumor Inhibiting Activity of 1,1,2,2-Tetraalkyl-1,2-diphenylethanes
Hartmann, Rolf W.,Kranzfelder, Gerhard,Angerer, Erwin, v.,Schoenenberger, Helmut
, p. 841 - 848 (2007/10/02)
Among the newly synthesized 1,1,2,2-tetraalkyl-1,2-diphenylethanes, 1,1,2,2-tetramethyl-1,2-bis(4'-hydroxyphenyl)ethane (23) and 1,1,2,2-tetramethyl-1,2-bis(3'-hydroxyphenyl)ethane (26) were the most active compounds regarding estradiol receptor affinity, exhibiting Ka values of 0.73*108 and 0.67*108 M-1, respectively.In vivo, 23 and 26 showed only very small uterotrophic activity in the mouse.They strongly inhibited (73percent) the estrone-stimulated mouse uterine growth.Tested on the 9,10-dimethyl-1,2-benzanthracene induced hormone-dependent mammary adenocarcinoma of the Sprague-Dawley rat, compounds 23 and 26 exhibited a dose-dependent inhibition of the tumor growth, having a strong effect at a dose of 20 (mg/kg)/day (compound 23).
