74396-78-4

Usage

Uses

Used in Chemical Synthesis:
(3Z)-7-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE 3-OXIME is used as a building block for the synthesis of other organic molecules. Its unique structure and functional groups make it a versatile component in creating a variety of chemical compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (3Z)-7-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE 3-OXIME is considered a potential drug candidate. Its oxime functionality may contribute to biological activities that could be harnessed for therapeutic purposes.
Used in Medicinal Chemistry Research:
(3Z)-7-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE 3-OXIME is also utilized in medicinal chemistry research to explore its potential biological activities. The presence of the trifluoromethyl group and the oxime group may impart specific properties that could be beneficial in the development of new pharmaceutical agents.

InChI:InChI=1/C9H5F3N2O2/c10-9(11,12)5-3-1-2-4-6(5)13-8(15)7(4)14-16/h1-3,16H,(H,13,14,15)

Upstream product

• 444-93-9 2-hydroxyimino-N-(2-trifluoromethyl-phenyl)-acetamide 
• 391-12-8 7-trifluoromethylisatin 

Downstream Products

• 58458-14-3 2-amino-3-trifluoromethylbenzonitrile 

Relevant academic research and scientific papers

Copper-Catalyzed Carbonyl Group Controlled Coupling of Isatin Oximes with Arylboronic Acids To Prepare N-Aryloxindole Nitrones

A variety of (E)-N-aryloxindole nitrones were prepared in good to excellent yields by using a copper-catalyzed coupling reaction of isatin oximes and arylboronic acids under mild conditions. Various arylboronic acids that contain sensitive functional groups were tolerated in the transformation, and detailed studies show that the carbonyl group of the isatin oximes serves as a ligand to control the formation of the (E)-oxindole nitrones. This method to prepare (E)-N-aryloxindole nitrones was easily performed on a gram scale and efficiently used to synthesize estrone-derived oxindole nitrone in high yield.

Synthesis of N-Aryl Oxindole Nitrones through a Metal-Free Selective N-Arylation Process

An efficient selective N-arylation of 3-(hydroxyimino)indolin-2-ones with diaryliodonium salts to prepare (Z)-N-aryl oxindole nitrones has been achieved under simple base-mediated conditions. The reaction tolerated a variety of diaryliodonium salts with diverse and sensitive functional groups. Studies on the oxime structures revealed that the pyrroline ring and carbonyl group in 3-(hydroxyimino)indolin-2-ones played important roles in the selective N-arylation process. The N-aryl oxindole nitrones could be prepared rapidly and easily at the gram scale.

Pronounced ionic liquid effect in the synthesis of biologically active isatin-3-oxime derivatives under acid catalysis

An efficient method was developed for the preparation of isatin-3-oxime derivatives with Bronsted and/or Lewis acids in imidazolium-based ionic liquids. Isatin-3-oxime bearing the electron donating methoxy group was equally obtained in good yields. The pr