7441-38-5Relevant academic research and scientific papers
A rapid and convenient synthesis of derivatives of imidazoles under Microwaveirradiation
Zhao, Na,Wang, Yu-Lu,Wang, Jin-Ye
, p. 535 - 538 (2005)
Anefficient and a quick microwave-assisted synthesis of benzimidazoles and trisubstituted imidazoles was developed. Three benzimidazoles were obtained as a result of the condensation of 1,2-phenylenediamine with carboxylic acids and acetoacetic ester without catalyst. A series of trisubstituted imidazoles were syn thesized by condensation of benzil, aromatical dehyde and ammonium acetate in the presence of glacial acetic acid.
Synthesis of 2,4,5-trisubstituted imidazoles, quinoxalines and 1,5-benzodiazepines over an eco-friendly and highly efficient ZrO2-Al2O3 catalyst
Thimmaraju,Shamshuddin, S. Z. Mohamed
, p. 60231 - 60243 (2016/07/11)
ZrO2-Al2O3 containing 80 mol% of ZrO2 was prepared by solution combustion, impregnation and precipitation methods. All the prepared catalytic materials were characterized by PXRD, NH3-TPD, N2 adsorption isotherms, FTIR, TEM, SEM, EDAX and ICP-OES techniques. These catalytic materials were used in a rapid, simple, versatile and efficient synthesis of 2,4,5-trisubstituted imidazoles under solvent-free conditions at moderate temperature in shorter reaction time (20 min). This is achieved by three-component cyclo-condensation of benzil, aldehydes and ammonium acetate in excellent yields. The derivatives of quinoxalines and 1,5-benzodiazepines were synthesized effectively by cyclo-condensation of 1,2-diamine with α-diketones and carbonyl compound with O-phenylenediamines respectively over ZrO2-Al2O3 at moderate temperature (80 °C) for the reaction time of 20-40 min in presence of ethanol as a solvent. The present method is experimentally simple, non-toxic and involves inexpensive reagents, clean reaction pathways and an eco-friendly catalyst. The catalytic materials used can be easily separated from the reaction mixture and reused for several reaction cycles without much loss of catalytic activity.
Simple and efficient method for the synthesis of highly substituted imidazoles catalyzed by benzotriazole
Xu, Feng,Wang, Nige,Tian, Youping,Li, Gaoqiang
, p. 668 - 675 (2013/06/27)
Benzotriazole is an efficient, readily available, and simple catalyst for the synthesis of 2,4,5-trisubstituted imidazoles in high yields from 1,2-diketones and aldehydes in the presence of NH4OAc via multi-components reaction. The significant features of this one-pot procedure are very simple operation, easy work-up and purification of products.
