74414-84-9Relevant academic research and scientific papers
Organic Sulfites containing a 1,2-Oxazine Ring
Tabei, Katsumi,Kawashima, Etsuko,Kato, Tetsuzo
, p. 330 - 336 (2007/10/02)
The reaction of 5-hydroxy-2-phenyltetrahydro-2H-1,2-oxazin-3-one derivatives (2) with thionyl chloride in the presence pyridine afforded a mixture of stereoisomers of bis(3-oxo-2-phenyltetrahydro-2H-1,2-oxazine-5-yl) sulfite derivatives (3) in total yields of 75-83percent.On high-performance liquid chromatography, two meso-diastereoisomers (3-I and 3-II) and a racemic compound (3-III) were isolated. Keywords: organic sulfites; bis(2-aryl-3-oxotetrahydro-2H-1,2-oxazine-5-yl) sulfite; 1,2-oxazine derivatives; thionyl chloride; esterefication; stereoisomer; HPLC; separation
