74416-91-4

Upstream product

• 7210-76-6 ethyl-2-amino-4-methylthiazole-5-carboxylate 
• 70-11-1 α-bromoacetophenone 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 92166-32-0 N-(3-methyl-6-phenyl-imidazo[2,1-b]thiazol-2-yl)-acetamide 
• 96812-51-0 3-methyl-6-phenyl-imidazo[2,1-b]thiazole-2-carbonyl azide 
• 81292-44-6 6,7-Dibenzoyl-3-methyl-pyrrolo[2,1-b]thiazole-2-carboxylic acid ethyl ester 
• 74416-88-9 2-ethyl 6,7-dimethyl-3-methylpyrrolo<2,1-b>thiazole-2,6,7-tricarboxylate 
• 74454-01-6 tetramethyl 3-phentylimidazo<1,2-a>pyridine-5,6,7,8-tetracarboxylate 
• 91803-42-8 3-methyl-6-phenyl-imidazo[2,1-b]thiazole-2-carboxylic acid hydrazide 

Relevant academic research and scientific papers

Microwave-assisted green synthesis of new imidazo[2,1-b]thiazole derivatives and their antimicrobial, antimalarial, and antitubercular activities

Abstract: We have synthesized some imidazo[2,1-b]thiazole derivatives by reaction of 1-(2-amino-4-methylthiazol-5-yl)ethanone or ethyl 2-amino-4-methylthiazole-5-carboxylate with α-bromo aralkyl ketones (phenacyl bromides) in presence of polyethylene glycol-400 (PEG-400) as efficient, inexpensive, biodegradable, and green reaction medium and catalyst (dual nature) under Microwave Irradiation (MWI) at 300?W as well as under thermal heating at 90?°C. Moreover, we also synthesized 1-(2-amino-4-methylthiazol-5-yl)ethanone and ethyl 2-amino-4-methylthiazole-5-carboxylate by one-pot reaction of acetyl acetone/ethyl acetoacetate with N-bromosuccinimide (NBS) and thiourea in presence of PEG-400 under microwave irradiation at 180?W. All synthesized compounds were screened for antimicrobial and antimalarial activities. All compounds were found to show good to excellent antibacterial activity, and some analogs exhibited good antimalarial activity.

IMIDAZO[2, 1-B]THIAZOLES AND THEIR USE AS PHARMACEUTICALS

The present invention relates to derivatives of imidazo[2,1-b]thiazoles of the formula (I), in which R, R1 to R3 and n have the meanings indicated in the claims, which modulate the transcription of endothelial nitric oxide (NO) synthase and are valuable pharmacologically active compounds. Specifically, the compounds of the formula I upregulate the expression of the enzyme endothelial NO synthase and can be applied in conditions in which an increased expression of said enzyme or an increased NO level or the normalization of a decreased NO level is desired. The invention further relates to processes for the preparation of compounds of the formula I, to pharmaceutical compositions comprising them, and to the use of compounds of the formula I for the manufacture of a medicament for the stimulation of the expression of endothelial NO synthase or for the treatment of various diseases including cardiovascular disorders such as atherosclerosis, thrombosis, coronary artery disease, hypertension and cardiac insufficiency, for example.