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α-N-Benzoyl-2-cyanohistamine is a chemical compound with the molecular formula C14H13N3O2. It is a derivative of histamine, an important molecule in the body that plays a role in immune responses and allergic reactions. The compound features a benzoyl group attached to the nitrogen atom at the alpha position, and a cyano group at the second carbon position. This structure gives it unique properties and potential applications in pharmaceutical research, particularly in the study of histamine receptors and their role in various physiological processes. Due to its complex structure, α-N-Benzoyl-2-cyanohistamine is typically synthesized in a laboratory setting and is not found naturally in the environment.

74419-68-4

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74419-68-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 74419-68-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,4,1 and 9 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 74419-68:
(7*7)+(6*4)+(5*4)+(4*1)+(3*9)+(2*6)+(1*8)=144
144 % 10 = 4
So 74419-68-4 is a valid CAS Registry Number.

74419-68-4Downstream Products

74419-68-4Relevant academic research and scientific papers

New Histamine and Histidine Analogues via Transformations of the 2-Trifluoromethyl Group

Kimoto, Hiroshi,Cohen, Louis A.

, p. 3831 - 3835 (2007/10/02)

α-N-Benzoyl-2-(trifluoromethyl)histamine has been transformed, via a difluorodiazafulvene intermediate, into 2-carboxy- and 2-(carbomethoxy)histamine. 2-Carboxy-L-histidine was prepared by a similar route. 2-(Carbomethoxy)-L-histidine was prepared by methanolysis of α-N-(tert-butoxycarbonyl)-2-(trifluoromethyl)-L-histidine and acid hydrolysis of the intermediate ortho ester. 2-Cyanohistamine and 2-cyano-L-histidine are best prepared by ammonolysis of the corresponding α-N-(tert-butoxycarbonyl)-2-(trifluoromethyl)imidazoles and acid cleavage of the protecting group.During the hydrolysis of N-benzoyl protecting groups in hot, aqueous mineral acid, decarboxylation of 2-carboxyimidazoles occurs gradually; this side reaction is repressed by use of concentrated acid.

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